Crystal structure of porcine pancreatic phospholipase A2 in complex with 1,2-dihydroxybenzene

Summary for 3O4M

Related3HSW 3L30 3L69 2B00 2B03 2B04
DescriptorPhospholipase A2, major isoenzyme, CALCIUM ION, CATECHOL, ... (4 entities in total)
Functional Keywordscatechol binding, pla2, pancreatic enzyme, disulfide bond, lipid degradation, lipoprotein, metal-binding, palmitate, pyrrolidone carboxylic acid, pancreas, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSus scrofa (Pig)
Cellular locationSecreted P00592
Total number of polymer chains1
Total molecular weight14199.98
Dileep, K.V.,Tintu, I.,Karthe, P.,Mandal, P.K.,Haridas, M.,Sadasivan, C. (deposition date: 2010-07-27, release date: 2010-08-25, Last modification date: 2011-11-23)
Primary citation
Dileep, K.V.,Tintu, I.,Mandal, P.K.,Karthe, P.,Haridas, M.,Sadasivan, C.
Binding to PLA(2) may contribute to the anti-inflammatory activity of catechol
Chem.Biol.Drug Des., 2011
PubMed: 21995306 (PDB entries with the same primary citation)
DOI: 10.1111/j.1747-0285.2011.01258.x
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25290.8%2.7%3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-16