1TVO
The structure of ERK2 in complex with a small molecule inhibitor
Summary for 1TVO
Entry DOI | 10.2210/pdb1tvo/pdb |
Descriptor | Mitogen-activated protein kinase 1, 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE (3 entities in total) |
Functional Keywords | kinase, protein-inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, spindle : P28482 |
Total number of polymer chains | 1 |
Total formula weight | 42558.78 |
Authors | Kinoshita, T. (deposition date: 2004-06-30, release date: 2005-09-13, Last modification date: 2024-03-13) |
Primary citation | Ohori, M.,Kinoshita, T.,Okubo, M.,Sato, K.,Yamazaki, A.,Arakawa, H.,Nishimura, S.,Inamura, N.,Nakajima, H.,Neya, M.,Miyake, H.,Fujii, T. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex Biochem.Biophys.Res.Commun., 336:357-363, 2005 Cited by PubMed: 16139248DOI: 10.1016/j.bbrc.2005.08.082 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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