1TVO
The structure of ERK2 in complex with a small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitogen-activated protein kinase 1 | polymer | 368 | 42231.4 | 1 | UniProt (P28482) Pfam (PF00069) In PDB | Homo sapiens (human) | ERK2, Extracellular signal-regulated kinase 2, ERK-2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1 |
| 2 | A | 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE | non-polymer | 327.3 | 1 | Chemie (FRZ) | |||
| 3 | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: P28482)
| PDB | External Database | Details |
|---|---|---|
| Gly 361 | - | cloning artifact |
| Asp 362 | - | cloning artifact |
| Leu 363 | - | cloning artifact |
| Gly 364 | - | cloning artifact |
| Ser 365 | - | cloning artifact |
| Asp 366 | - | cloning artifact |
| Glu 367 | - | cloning artifact |
| Leu 368 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42231.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 327.3 | |
| All* | Total formula weight | 42558.8 |
