6OC9
| S8 phosphorylated beta amyloid 40 fibrils | Descriptor: | Amyloid-beta precursor protein, PHOSPHONATE | Authors: | Qiang, W, Hu, Z.W. | Deposit date: | 2019-03-22 | Release date: | 2019-06-05 | Last modified: | 2024-05-01 | Method: | SOLID-STATE NMR | Cite: | Molecular structure of an N-terminal phosphorylated beta-amyloid fibril. Proc.Natl.Acad.Sci.USA, 116, 2019
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5NX1
| Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | Descriptor: | Amyloid-beta A4 protein, Kallikrein-6 | Authors: | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | Deposit date: | 2017-05-09 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.853 Å) | Cite: | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
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5NX3
| Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | Descriptor: | Amyloid-beta A4 protein, Kallikrein-6 | Authors: | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | Deposit date: | 2017-05-09 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.296 Å) | Cite: | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
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8BG9
| Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains | ABeta | Descriptor: | Amyloid-beta protein 40 | Authors: | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2022-10-27 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
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5OQV
| Near-atomic resolution fibril structure of complete amyloid-beta(1-42) by cryo-EM | Descriptor: | Amyloid beta A4 protein | Authors: | Gremer, L, Schoelzel, D, Schenk, C, Reinartz, E, Labahn, J, Ravelli, R, Tusche, M, Lopez-Iglesias, C, Hoyer, W, Heise, H, Willbold, D, Schroeder, G.F. | Deposit date: | 2017-08-14 | Release date: | 2017-09-13 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Fibril structure of amyloid-beta (1-42) by cryo-electron microscopy. Science, 358, 2017
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8OQZ
| Structure of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc in complex with Ab46 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Odorcic, I, Chavez Gutierrez, L, Efremov, R.G. | Deposit date: | 2023-04-12 | Release date: | 2024-04-24 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Apo and A beta 46-bound gamma-secretase structures provide insights into amyloid-beta processing by the APH-1B isoform. Nat Commun, 15, 2024
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6ITU
| Crystal Structure of the GULP1 PTB domain-APP peptide complex | Descriptor: | 1,2-ETHANEDIOL, Amyloid beta A4 protein, PTB domain-containing engulfment adapter protein 1, ... | Authors: | Yung, K.W.Y, Lau, K.F, Ngo, J.C.K. | Deposit date: | 2018-11-26 | Release date: | 2019-08-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Attenuation of amyloid-beta generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35. Faseb J., 33, 2019
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4KML
| Probing the N-terminal beta-sheet conversion in the crystal structure of the full-length human prion protein bound to a Nanobody | Descriptor: | Major prion protein, Nanobody | Authors: | Abskharon, R.N.N, Giachin, G, Wohlkonig, A, Soror, S.H, Pardon, E, Legname, G, Steyaert, J. | Deposit date: | 2013-05-08 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Probing the N-Terminal beta-Sheet Conversion in the Crystal Structure of the Human Prion Protein Bound to a Nanobody. J.Am.Chem.Soc., 136, 2014
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6LNI
| Cryo-EM structure of amyloid fibril formed by full-length human prion protein | Descriptor: | Major prion protein | Authors: | Wang, L.Q, Zhao, K, Yuan, H.Y, Wang, Q, Guan, Z.Y, Tao, J, Li, X.N, Hao, M.M, Chen, J, Zhang, D.L, Zhu, H.L, Yin, P, Liu, C, Liang, Y. | Deposit date: | 2019-12-30 | Release date: | 2020-06-10 | Last modified: | 2020-06-24 | Method: | ELECTRON MICROSCOPY (2.702 Å) | Cite: | Cryo-EM structure of an amyloid fibril formed by full-length human prion protein. Nat.Struct.Mol.Biol., 27, 2020
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1PY1
| Complex of GGA1-VHS domain and beta-secretase C-terminal phosphopeptide | Descriptor: | ADP-ribosylation factor binding protein GGA1, Beta-secretase | Authors: | Zhu, G, Zhang, X.C. | Deposit date: | 2003-07-07 | Release date: | 2003-11-04 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase)
cytosolic domain with the VHS domain of GGA proteins. Biochemistry, 42, 2003
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1QLX
| Human prion protein | Descriptor: | PRION PROTEIN | Authors: | Zahn, R, Liu, A, Luhrs, T, Wuthrich, K. | Deposit date: | 1999-09-17 | Release date: | 1999-12-16 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | NMR Solution Structure of the Human Prion Protein Proc.Natl.Acad.Sci.USA, 97, 2000
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1QLZ
| Human prion protein | Descriptor: | PRION PROTEIN | Authors: | Zahn, R, Liu, A, Luhrs, T, Wuthrich, K. | Deposit date: | 1999-09-20 | Release date: | 1999-12-16 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | NMR Solution Structure of the Human Prion Protein Proc.Natl.Acad.Sci.USA, 97, 2000
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3BKM
| Structure of anti-amyloid-beta Fab WO2 (Form A, P212121) | Descriptor: | SODIUM ION, WO2 IgG2a Fab fragment Heavy Chain, WO2 IgG2a Fab fragment Light Chain Kappa, ... | Authors: | Miles, L.A, Wun, K.S, Crespi, G.A, Fodero-Tavoletti, M, Galatis, D, Bageley, C.J, Beyreuther, K, Masters, C.L, Cappai, R, McKinstry, W.J, Barnham, K.J, Parker, M.W. | Deposit date: | 2007-12-07 | Release date: | 2008-04-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope. J.Mol.Biol., 377, 2008
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6TI7
| Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils | Descriptor: | Amyloid-beta precursor protein | Authors: | Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C. | Deposit date: | 2019-11-21 | Release date: | 2020-07-22 | Last modified: | 2024-06-19 | Method: | SOLID-STATE NMR | Cite: | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils. Chem.Commun.(Camb.), 56, 2020
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8BFB
| Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure (Methoxy-X04-labelled mice) | Descriptor: | Amyloid-beta precursor protein | Authors: | Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W. | Deposit date: | 2022-10-24 | Release date: | 2023-05-31 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain. Nat Commun, 14, 2023
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8BFA
| Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure | Descriptor: | Amyloid-beta precursor protein | Authors: | Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W. | Deposit date: | 2022-10-24 | Release date: | 2023-05-31 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain. Nat Commun, 14, 2023
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6TI6
| Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils | Descriptor: | Amyloid-beta precursor protein | Authors: | Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C. | Deposit date: | 2019-11-21 | Release date: | 2020-07-22 | Last modified: | 2024-06-19 | Method: | SOLID-STATE NMR | Cite: | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils. Chem.Commun.(Camb.), 56, 2020
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6O4J
| Amyloid Beta KLVFFAENVGS 16-26 D23N Iowa mutation | Descriptor: | Amyloid-beta precursor protein | Authors: | Griner, S.L, Sawaya, M.R, Rodriguez, J.A, Cascio, D, Gonen, T. | Deposit date: | 2019-02-28 | Release date: | 2019-10-30 | Last modified: | 2023-10-11 | Method: | ELECTRON CRYSTALLOGRAPHY (1.402 Å) | Cite: | Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau. Elife, 8, 2019
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6SHS
| Abeta fibril (Morphology I) | Descriptor: | Amyloid-beta precursor protein | Authors: | Kollmer, M, Fandrich, M. | Deposit date: | 2019-08-08 | Release date: | 2019-11-06 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM structure and polymorphism of A beta amyloid fibrils purified from Alzheimer's brain tissue. Nat Commun, 10, 2019
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6SZF
| Solution structure of the amyloid beta-peptide (1-42) | Descriptor: | Amyloid-beta precursor protein | Authors: | Grimaldi, M, Santoro, A, Stillitano, I, Buonocore, M, D'Ursi, A.M. | Deposit date: | 2019-10-02 | Release date: | 2020-10-14 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Exploring the Early Stages of the Amyloid A beta (1-42) Peptide Aggregation Process: An NMR Study. Pharmaceuticals, 14, 2021
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6TI5
| A New Structural Model of Abeta(1-40) Fibrils | Descriptor: | Amyloid-beta precursor protein | Authors: | Bertini, I, Gonnelli, L, Luchinat, C, Mao, J, Nesi, A. | Deposit date: | 2019-11-21 | Release date: | 2020-07-22 | Last modified: | 2024-06-19 | Method: | SOLID-STATE NMR | Cite: | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils. Chem.Commun.(Camb.), 56, 2020
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8OTF
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5ONR
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5ONQ
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5ONP
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