5NX1

Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy

Summary for 5NX1

Entry DOI	10.2210/pdb5nx1/pdb
Descriptor	Kallikrein-6, Amyloid-beta A4 protein, ... (5 entities in total)
Functional Keywords	serine_protease, inhibitor, complex, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	42881.85
Authors	Shahar, A.,Sananes, A.,Radisky, E.S.,Papo, N. (deposition date: 2017-05-09, release date: 2018-05-30, Last modification date: 2024-01-17)
Primary citation	Sananes, A.,Cohen, I.,Shahar, A.,Hockla, A.,De Vita, E.,Miller, A.K.,Radisky, E.S.,Papo, N. A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293:12663-12680, 2018 Cited by PubMed: 29934309 DOI: 10.1074/jbc.RA117.000871 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.853 Å)

Structure validation