8OQZ

Structure of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc in complex with Ab46

Summary for 8OQZ

• Entry DOI: 10.2210/pdb8oqz/pdb
• EMDB information: 17113
• Descriptor: Nicastrin, Presenilin-1 CTF12, Gamma-secretase subunit APH-1B, ... (8 entities in total)
• Functional Keywords: intramembrane proteolysis, protease, di-aspartyl protease, alzheimer's disease, complex, amyloid beta, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 192299.82

Authors

Odorcic, I.,Chavez Gutierrez, L.,Efremov, R.G. (deposition date: 2023-04-12, release date: 2024-04-24, Last modification date: 2024-06-19)

• Primary citation: Odorcic, I.,Hamed, M.B.,Lismont, S.,Chavez-Gutierrez, L.,Efremov, R.G.; Apo and A beta 46-bound gamma-secretase structures provide insights into amyloid-beta processing by the APH-1B isoform.; Nat Commun, 15:4479-4479, 2024; PubMed: 38802343; DOI: 10.1038/s41467-024-48776-2

Experimental method

ELECTRON MICROSCOPY (3.4 Å)