8BFB

Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure (Methoxy-X04-labelled mice)

Summary for 8BFB

Entry DOI	10.2210/pdb8bfb/pdb
EMDB information	16019
Descriptor	Amyloid-beta precursor protein (1 entity in total)
Functional Keywords	amyloid, fibril, helical, cross-beta, beta amyloid, protein fibril, ex vivo, arctic mutant, alzheimers disease
Biological source	Mus musculus (house mouse)
Total number of polymer chains	10
Total formula weight	44480.25
Authors	Wilkinson, M.,Leistner, C.,Burgess, A.,Goodfellow, S.,Deuchars, S.,Ranson, N.A.,Radford, S.E.,Frank, R.A.W. (deposition date: 2022-10-24, release date: 2023-05-31)
Primary citation	Leistner, C.,Wilkinson, M.,Burgess, A.,Lovatt, M.,Goodbody, S.,Xu, Y.,Deuchars, S.,Radford, S.E.,Ranson, N.A.,Frank, R.A.W. The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain. Nat Commun, 14:2833-2833, 2023 Cited by PubMed: 37198197 DOI: 10.1038/s41467-023-38495-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation