3BKM

Structure of anti-amyloid-beta Fab WO2 (Form A, P212121)

Summary for 3BKM

Entry DOI	10.2210/pdb3bkm/pdb
Related	3BAE 3BKC 3BKJ
Descriptor	WO2 IgG2a Fab fragment Light Chain Kappa, WO2 IgG2a Fab fragment Heavy Chain, SODIUM ION, ... (5 entities in total)
Functional Keywords	abeta, amyloid beta peptide, fab, wo2, alzheimer's disease, immunotherapies, app, immune system
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	2
Total formula weight	52362.16
Authors	Miles, L.A.,Wun, K.S.,Crespi, G.A.,Fodero-Tavoletti, M.,Galatis, D.,Bageley, C.J.,Beyreuther, K.,Masters, C.L.,Cappai, R.,McKinstry, W.J.,Barnham, K.J.,Parker, M.W. (deposition date: 2007-12-07, release date: 2008-04-15, Last modification date: 2023-11-01)
Primary citation	Miles, L.A.,Wun, K.S.,Crespi, G.A.,Fodero-Tavoletti, M.T.,Galatis, D.,Bagley, C.J.,Beyreuther, K.,Masters, C.L.,Cappai, R.,McKinstry, W.J.,Barnham, K.J.,Parker, M.W. Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope. J.Mol.Biol., 377:181-192, 2008 Cited by PubMed: 18237744 DOI: 10.1016/j.jmb.2007.12.036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation