PDB: 106 resultsInfo pagesStatus searchChemie searchBIRD

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5HCE	Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus appendiculatus RaCI1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ... Authors: Jore, M.M, Johnson, S, Lea, S.M. Deposit date: 2016-01-04 Release date: 2016-03-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.12 Å) Cite: Structural basis for therapeutic inhibition of complement C5. Nat.Struct.Mol.Biol., 23, 2016
7AD6	Crystal structure of human complement C5 in complex with the K92 bovine knob domain peptide. Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CYSTEINE, ... Authors: Macpherson, A, van den Elsen, J.M.H, Schulze, M.E, Birtley, J.R. Deposit date: 2020-09-14 Release date: 2021-03-10 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.75 Å) Cite: The allosteric modulation of Complement C5 by knob domain peptides. Elife, 10, 2021
7AD7	Crystal structure of human complement C5 in complex with the K8 bovine knob domain peptide. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Macpherson, A, van den Elsen, J.M.H, Schulze, M.E, Birtley, J.R. Deposit date: 2020-09-14 Release date: 2021-03-10 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The allosteric modulation of Complement C5 by knob domain peptides. Elife, 10, 2021
7ZGJ	Trypanosoma brucei gambiense ISG65 in complex with human complement component C3 Descriptor: 65 kDa invariant surface glycoprotein, putative, Complement C3, ... Authors: Suelzen, H, Zoll, S. Deposit date: 2022-04-03 Release date: 2023-04-05 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. Nat Commun, 14, 2023
7ZGK	Trypanosoma brucei gambiense ISG65 in complex with human complement component C3b Descriptor: 65 kDa invariant surface glycoprotein, putative, Complement C3 beta chain, ... Authors: Suelzen, H, Zoll, S. Deposit date: 2022-04-03 Release date: 2023-04-05 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.59 Å) Cite: Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. Nat Commun, 14, 2023
8AYH	Structure of Complement C5 in Complex with small molecule inhibitor and CVF Descriptor: 5-methoxy-2-[[(1~{S})-1-(2-methoxyphenyl)ethyl]carbamoylamino]-4-(4-methylpentoxy)benzoic acid, Cobra venom factor, Complement C5 alpha chain, ... Authors: Srinivas, H. Deposit date: 2022-09-02 Release date: 2022-12-21 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: A small-molecule inhibitor of C5 complement protein. Nat.Chem.Biol., 15, 2019
7B2Q	Cryo-EM structure of complement C4b in complex with nanobody B12 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-C4b nanobody B12, ... Authors: Oosterheert, W, De la O Becerra, K.I, Gros, P. Deposit date: 2020-11-27 Release date: 2022-03-02 Last modified: 2022-05-04 Method: ELECTRON MICROSCOPY (3.76 Å) Cite: Multifaceted Activities of Seven Nanobodies against Complement C4b. J Immunol., 208, 2022
7B2M	Cryo-EM structure of complement C4b in complex with nanobody E3 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-C4b nanobody E3, Complement C4 alpha chain, ... Authors: Oosterheert, W, De la O Becerra, K.I, van den Bos, R.M, Gros, P. Deposit date: 2020-11-27 Release date: 2022-03-02 Last modified: 2022-05-04 Method: ELECTRON MICROSCOPY (3.39 Å) Cite: Multifaceted Activities of Seven Nanobodies against Complement C4b. J Immunol., 208, 2022
7B2P	Cryo-EM structure of complement C4b in complex with nanobody B5 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C4 alpha chain, ... Authors: Oosterheert, W, De la O Becerra, K.I, Gros, P. Deposit date: 2020-11-27 Release date: 2022-03-02 Last modified: 2022-05-04 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: Multifaceted Activities of Seven Nanobodies against Complement C4b. J Immunol., 208, 2022
7O7Q	(h-alpha2M)4 trypsin-activated state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7O7M	(h-alpha2M)4 native II Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (6.6 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7O7O	(h-alpha2M)4 semiactivated II state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7Q61	Structure of TEV conjugated A2ML1 (A2ML1-TC) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1 Authors: Nielsen, N.S, Zarantonello, A, Andersen, G.R. Deposit date: 2021-11-05 Release date: 2022-04-20 Last modified: 2022-11-02 Method: ELECTRON MICROSCOPY (2.88 Å) Cite: Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. Nat Commun, 13, 2022
7O7N	(h-alpha2M)4 semiactivated I state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (7.3 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7O7R	(h-alpha2M)4 plasmin-activated I state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7Q1Y	X-ray structure of human A2ML1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1, ... Authors: Andersen, G.R, Zarantonello, A, Enghild, J.J, Nielsen, N.S. Deposit date: 2021-10-22 Release date: 2022-04-20 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (4.4 Å) Cite: Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. Nat Commun, 13, 2022
7O7P	(h-alpha2M)4 activated state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7Q62	Structure of TEV cleaved A2ML1 dimer (A2ML1-TT dimer) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1 Authors: Nielsen, N.S, Zarantonello, A, Andersen, G.R. Deposit date: 2021-11-05 Release date: 2022-04-20 Last modified: 2022-11-02 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. Nat Commun, 13, 2022
7Q5Z	Cryo-EM structure of native human A2ML1 Descriptor: Alpha-2-macroglobulin-like protein 1 Authors: Zarantonello, A, Nielsen, N.S, Andersen, G.R. Deposit date: 2021-11-05 Release date: 2022-04-20 Last modified: 2022-11-02 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. Nat Commun, 13, 2022
7Q60	Structure of TEV cleaved A2ML1 (A2ML1-TE) Descriptor: Alpha-2-macroglobulin-like protein 1 Authors: Nielsen, N.S, Zarantonello, A, Andersen, G.R. Deposit date: 2021-11-05 Release date: 2022-04-20 Last modified: 2022-11-02 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. Nat Commun, 13, 2022
7O7S	(h-alpha2M)4 plasmin-activated II state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7O7L	(h-alpha2M)4 native I Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-20 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7QIV	Structure of human C3b in complex with the EWE nanobody Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... Authors: Pedersen, H, Andersen, G.R. Deposit date: 2021-12-16 Release date: 2022-02-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity. Front Immunol, 13, 2022
7OP0	Crystal structure of complement C5 in complex with chemically synthesized K92 knob domain. Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, ... Authors: Macpherson, A, van der Elsen, J.M.H, Schulze, M.E, Birtley, J.R. Deposit date: 2021-05-28 Release date: 2022-04-06 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.57 Å) Cite: The Chemical Synthesis of Knob Domain Antibody Fragments. Acs Chem.Biol., 16, 2021
7S62	Locally refined protomer structure of native-form oocyte/egg Alpha-2-Macroglobulin (A2Moo) tetramer Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha 2-macroglobulin Authors: Arimura, Y, Funabiki, H. Deposit date: 2021-09-12 Release date: 2022-01-05 Last modified: 2022-01-19 Method: ELECTRON MICROSCOPY (3.65 Å) Cite: Structural Mechanics of the Alpha-2-Macroglobulin Transformation. J.Mol.Biol., 434, 2021

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