7O7R

(h-alpha2M)4 plasmin-activated I state

Summary for 7O7R

Entry DOI	10.2210/pdb7o7r/pdb
EMDB information	12754
Descriptor	Alpha-2-macroglobulin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	alpha2-macroglobulin, proteinase, serum proteostasis, hydrolase inhibitor, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	662328.18
Authors	Luque, D.,Goulas, T.,Mata, C.P.,Mendes, S.R.,Gomis-Ruth, F.X.,Caston, J.R. (deposition date: 2021-04-13, release date: 2022-04-13, Last modification date: 2022-05-11)
Primary citation	Luque, D.,Goulas, T.,Mata, C.P.,Mendes, S.R.,Gomis-Ruth, F.X.,Caston, J.R. Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119:e2200102119-e2200102119, 2022 Cited by PubMed: 35500114 DOI: 10.1073/pnas.2200102119 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.9 Å)

Structure validation