7O7M
(h-alpha2M)4 native II
Summary for 7O7M
Entry DOI | 10.2210/pdb7o7m/pdb |
EMDB information | 12748 |
Descriptor | Alpha-2-macroglobulin, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | alpha2-macroglobulin, proteinase, serum proteostasis, hydrolase inhibitor, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 663130.91 |
Authors | Luque, D.,Goulas, T.,Mata, C.P.,Mendes, S.R.,Gomis-Ruth, F.X.,Caston, J.R. (deposition date: 2021-04-13, release date: 2022-04-13, Last modification date: 2022-05-11) |
Primary citation | Luque, D.,Goulas, T.,Mata, C.P.,Mendes, S.R.,Gomis-Ruth, F.X.,Caston, J.R. Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119:e2200102119-e2200102119, 2022 Cited by PubMed: 35500114DOI: 10.1073/pnas.2200102119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (6.6 Å) |
Structure validation
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