7B2Q

Cryo-EM structure of complement C4b in complex with nanobody B12

Summary for 7B2Q

• Entry DOI: 10.2210/pdb7b2q/pdb
• Related: 7B2M 7B2P
• EMDB information: 11988 11989 11990
• Descriptor: Complement C4 beta chain, Complement C4 alpha chain, Complement C4 gamma chain, ... (6 entities in total)
• Functional Keywords: complement, nanobody, c4b, inhibitor, complement classical pathway, nanobody-antigen complex, immune system
• Biological source: Lama glama (Llama); More
• Total number of polymer chains: 4
• Total formula weight: 205508.37

Authors

Oosterheert, W.,De la O Becerra, K.I.,Gros, P. (deposition date: 2020-11-27, release date: 2022-03-02, Last modification date: 2022-05-04)

• Primary citation: De la O Becerra, K.I.,Oosterheert, W.,van den Bos, R.M.,Xenaki, K.T.,Lorent, J.H.,Ruyken, M.,Schouten, A.,Rooijakkers, S.H.M.,van Bergen En Henegouwen, P.M.P.,Gros, P.; Multifaceted Activities of Seven Nanobodies against Complement C4b.; J Immunol., 208:2207-2219, 2022; PubMed: 35428691; DOI: 10.4049/jimmunol.2100647

Experimental method

ELECTRON MICROSCOPY (3.76 Å)