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8Q4S	Crystal structure of phosphoserine phosphatase (SerB) from Brucella melitensis in complex with AP4 and magnesium. Descriptor: (2S)-2-amino-4-phosphonobutanoic acid, GLYCEROL, MAGNESIUM ION, ... Authors: Scaillet, T, Wouters, J. Deposit date: 2023-08-07 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Crystal structure of phosphoserine phosphatase (SerB) from Brucella melitensis in complex with AP4 and magnesium. To Be Published
1BXR	STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP Descriptor: CARBAMOYL-PHOSPHATE SYNTHASE, CHLORIDE ION, L-ornithine, ... Authors: Thoden, J.B, Wesenberg, G, Raushel, F.M, Holden, H.M. Deposit date: 1998-10-08 Release date: 1999-04-20 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding. Biochemistry, 38, 1999
8RKD	TadA/CpaF with AMPPNP Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Hohl, M, Low, H. Deposit date: 2023-12-24 Release date: 2024-08-14 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Bidirectional pilus processing in the Tad pilus system motor CpaF. Nat Commun, 15, 2024
1AOK	VIPOXIN COMPLEX Descriptor: ACETATE ION, VIPOXIN COMPLEX Authors: Perbandt, M, Wilson, J.C, Eschenburg, S, Betzel, C. Deposit date: 1997-07-07 Release date: 1998-01-21 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of vipoxin at 2.0 A: an example of regulation of a toxic function generated by molecular evolution. FEBS Lett., 412, 1997
8ZNG	Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus in complex with NADPH and AKG in the steady stage of reaction Descriptor: 2-OXOGLUTARIC ACID, Glutamate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Wakabayashi, T, Nakasako, M. Deposit date: 2024-05-26 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action To Be Published
8ZND	Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH and a substrate in the steady stage of reaction Descriptor: Glutamate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Wakabayashi, T, Nakasako, M. Deposit date: 2024-05-26 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (2.53 Å) Cite: Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action To Be Published
8ZNE	Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus in complex with NADP and GLU in the steady stage of reaction Descriptor: GLUTAMIC ACID, Glutamate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Wakabayashi, T, Nakasako, M. Deposit date: 2024-05-26 Release date: 2024-06-26 Method: ELECTRON MICROSCOPY (2.64 Å) Cite: Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by cryoEM-sampling metastable conformation in action To Be Published
8ZNB	Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH in the steady stage of reaction Descriptor: Glutamate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Wakabayashi, T, Nakasako, M. Deposit date: 2024-05-26 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (2.53 Å) Cite: Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action To Be Published
8ZNC	Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH, AKG in the steady stage of reaction Descriptor: 2-OXOGLUTARIC ACID, AMMONIUM ION, Glutamate dehydrogenase, ... Authors: Wakabayashi, T, Nakasako, M. Deposit date: 2024-05-26 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (2.41 Å) Cite: Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action To Be Published
8WZM	Human erythrocyte catalase with CTAB as additive during EM sample preparation Descriptor: Catalase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE Authors: Yadav, S, Vinothkumar, K.R. Deposit date: 2023-11-02 Release date: 2024-07-10 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Factors affecting macromolecule orientations in thin films formed in cryo-EM. Acta Crystallogr D Struct Biol, 80, 2024
9AUC	Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin gene-related peptide 1, ... Authors: Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M. Deposit date: 2024-02-28 Release date: 2024-04-24 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein. Biochemistry, 63, 2024
8P2I	Cryo-EM structure of Pyrococcus furiosus apo form RNA polymerase contracted clamp conformation with Spt4/5 Descriptor: DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit Rpo11, DNA-directed RNA polymerase subunit Rpo12, ... Authors: Tarau, D.M, Reichelt, R, Heiss, F.B, Pilsl, M, Hausner, W, Engel, C, Grohmann, D. Deposit date: 2023-05-16 Release date: 2024-04-24 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment. Nucleic Acids Res., 52, 2024
7OTO	The structure of MutS bound to two molecules of AMPPNP Descriptor: DNA mismatch repair protein MutS, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER Authors: Lamers, M.H, Borsellini, A, Friedhoff, P, Kunetsky, V. Deposit date: 2021-06-10 Release date: 2022-01-12 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair. Nat.Struct.Mol.Biol., 29, 2022
6OE2	X-Ray Structure of the C-terminal domain (277-440) of Putative chitobiase from Bacteroides thetaiotaomicron. Northeast Structural Genomics Consortium Target BtR324A. Re-refinement of 3GGL with correct metal Mn replacing Zn. New metal confirmed with PIXE analysis of original sample. Descriptor: Chitobiase, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION Authors: Snell, E.H, Garman, E.F, Lowe, E.D. Deposit date: 2019-03-27 Release date: 2019-12-25 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3 Å) Cite: High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application. J.Am.Chem.Soc., 142, 2020
6ODY	Cryo-EM structure of Helicobacter pylori VacA hexamer Descriptor: Vacuolating cytotoxin autotransporter Authors: Erwin, A.L, Cover, T.L, Ohi, M.D. Deposit date: 2019-03-27 Release date: 2019-09-25 Last modified: 2019-12-04 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization. J.Mol.Biol., 431, 2019
8F1I	SigN RNA polymerase early-melted intermediate bound to mismatch fragment dhsU36mm1 (-12T) Descriptor: DNA (36-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Mueller, A.U, Chen, J, Darst, S.A. Deposit date: 2022-11-05 Release date: 2023-04-05 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3 Å) Cite: A general mechanism for transcription bubble nucleation in bacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
8F1J	SigN RNA polymerase early-melted intermediate bound to mismatch DNA fragment dhsU36mm2 (-12A) Descriptor: DNA (36-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Mueller, A.U, Chen, J, Darst, S.A. Deposit date: 2022-11-05 Release date: 2023-04-05 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: A general mechanism for transcription bubble nucleation in bacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
8F1K	SigN RNA polymerase early-melted intermediate bound to full duplex DNA fragment dhsU36 (-12T) Descriptor: DNA (36-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Mueller, A.U, Chen, J, Darst, S.A. Deposit date: 2022-11-05 Release date: 2023-04-05 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: A general mechanism for transcription bubble nucleation in bacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
8ORQ	Cryo-EM structure of Pyrococcus furiosus apo form RNA polymerase open clamp conformation Descriptor: DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit Rpo11, DNA-directed RNA polymerase subunit Rpo12, ... Authors: Tarau, D.M, Reichelt, R, Heiss, F.B, Pilsl, M, Hausner, W, Engel, C, Grohmann, D. Deposit date: 2023-04-17 Release date: 2024-04-24 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment. Nucleic Acids Res., 52, 2024
7YS6	Cryo-EM structure of the Serotonin 6 (5-HT6) receptor-DNGs-scFv16 complex Descriptor: 5-hydroxytryptamine receptor 6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Zhao, Q.Y, Wang, Y.F, He, L, Wang, S, Cong, Y. Deposit date: 2022-08-11 Release date: 2023-03-29 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural insights into constitutive activity of 5-HT 6 receptor. Proc.Natl.Acad.Sci.USA, 120, 2023
8FR8	Structure of Mycobacterium smegmatis Rsh bound to a 70S translation initiation complex Descriptor: 16S rRNA (1511-MER), 23S rRNA (3119-MER), 30S ribosomal protein S10, ... Authors: Majumdar, S, Sharma, M.R, Manjari, S.R, Banavali, N.K, Agrawal, R.K. Deposit date: 2023-01-06 Release date: 2023-05-17 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Starvation sensing by mycobacterial RelA/SpoT homologue through constitutive surveillance of translation. Proc.Natl.Acad.Sci.USA, 120, 2023
7JWY	Structure of SARS-CoV-2 spike at pH 4.5 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Zhou, T, Tsybovsky, Y, Kwong, P.D. Deposit date: 2020-08-26 Release date: 2020-11-25 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
8RBO	Cryo-EM structure of Pyrococcus furiosus apo form RNA polymerase contracted clamp conformation Descriptor: DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit Rpo11, DNA-directed RNA polymerase subunit Rpo12, ... Authors: Tarau, D.M, Reichelt, R, Heiss, F.B, Pilsl, M, Hausner, W, Engel, C, Grohmann, D. Deposit date: 2023-12-04 Release date: 2024-04-24 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.02 Å) Cite: Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment. Nucleic Acids Res., 52, 2024
8G4L	Cryo-EM structure of the human cardiac myosin filament Descriptor: Myosin light chain 3, Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, ... Authors: Dutta, D, Nguyen, V, Padron, R, Craig, R. Deposit date: 2023-02-10 Release date: 2023-11-01 Last modified: 2023-12-06 Method: ELECTRON MICROSCOPY (6.4 Å) Cite: Cryo-EM structure of the human cardiac myosin filament. Nature, 623, 2023
8ZMU	GLUTAMATE DEHYDROGENASE (W89F-MUTANT) FROM THERMOCOCCUS PROFUNDUS IN THE UNLIGANDED STATE Descriptor: ACETIC ACID, GLYCEROL, Glutamate dehydrogenase, ... Authors: Wakabayashi, T, Matsui, Y, Masayoshi, M. Deposit date: 2024-05-23 Release date: 2024-06-05 Method: X-RAY DIFFRACTION (2.028 Å) Cite: Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by cryoEM-sampling metastable conformation in action To Be Published

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