8ZNC
Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH, AKG in the steady stage of reaction
Summary for 8ZNC
Entry DOI | 10.2210/pdb8znc/pdb |
Related | 8ZMU |
EMDB information | 60267 |
Descriptor | Glutamate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-OXOGLUTARIC ACID, ... (5 entities in total) |
Functional Keywords | oxidoreductase, complex, nadph, 2-oxoglutarate, mutant |
Biological source | Thermococcus profundus |
Total number of polymer chains | 1 |
Total formula weight | 47269.56 |
Authors | |
Primary citation | Wakabayashi, T.,Oide, M.,Matsui, Y.,Nakasako, M. Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action To Be Published, |
Experimental method | ELECTRON MICROSCOPY (2.41 Å) |
Structure validation
Download full validation report