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8ZND

Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH and a substrate in the steady stage of reaction

Summary for 8ZND
Entry DOI10.2210/pdb8znd/pdb
Related8ZMU
EMDB information60268
DescriptorGlutamate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
Functional Keywordsoxidoreductase, complex, nadph, substrate, mutant
Biological sourceThermococcus profundus
Total number of polymer chains1
Total formula weight47105.43
Authors
Wakabayashi, T.,Nakasako, M. (deposition date: 2024-05-26, release date: 2024-06-12)
Primary citationWakabayashi, T.,Oide, M.,Matsui, Y.,Nakasako, M.
Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action
To Be Published,
Experimental method
ELECTRON MICROSCOPY (2.53 Å)
Structure validation

222415

PDB entries from 2024-07-10

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