3DSH
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![BU of 3dsh by Molmil](/molmil-images/mine/3dsh) | Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain | Descriptor: | Interferon regulatory factor 5 | Authors: | Chen, W, Lam, S.S, Srinath, H, Jiang, Z, Correia, J.J, Schiffer, C, Fitzgerald, K.A, Lin, K, Royer Jr, W.E. | Deposit date: | 2008-07-12 | Release date: | 2008-10-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat.Struct.Mol.Biol., 15, 2008
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8T5L
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![BU of 8t5l by Molmil](/molmil-images/mine/8t5l) | Crystal structure of STING CTD in complex with 2'3'-cGAMP | Descriptor: | Stimulator of interferon genes protein, cGAMP | Authors: | Li, Y, Li, P, Sun, D. | Deposit date: | 2023-06-13 | Release date: | 2023-07-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants. Biorxiv, 2023
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8T5K
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![BU of 8t5k by Molmil](/molmil-images/mine/8t5k) | Crystal structure of STING CTD in complex with BDW-OH | Descriptor: | Stimulator of interferon genes protein, {[(4S)-8,9-dimethylthieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3-yl]sulfanyl}acetic acid | Authors: | Li, Y, Li, P, Sun, D. | Deposit date: | 2023-06-13 | Release date: | 2023-07-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants. Biorxiv, 2023
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6MYD
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![BU of 6myd by Molmil](/molmil-images/mine/6myd) | Structure of zebrafish TRAF6 in complex with STING CTT | Descriptor: | STING CTT, Transmembrane protein 173, SULFATE ION, ... | Authors: | de Oliveira Mann, C.C, Orzalli, M.H, King, D.S, Kagan, J.C, Lee, A.S.Y, Kranzusch, P.J. | Deposit date: | 2018-11-01 | Release date: | 2019-05-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.399 Å) | Cite: | Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-kappa B Signaling Adaptation. Cell Rep, 27, 2019
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4MKP
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![BU of 4mkp by Molmil](/molmil-images/mine/4mkp) | Crystal structure of human cGAS apo form | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION | Authors: | Kato, K, Ishii, R, Ishitani, R, Nureki, O. | Deposit date: | 2013-09-05 | Release date: | 2013-10-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.953 Å) | Cite: | Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS Plos One, 8, 2013
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6NT9
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![BU of 6nt9 by Molmil](/molmil-images/mine/6nt9) | Cryo-EM structure of the complex between human TBK1 and chicken STING | Descriptor: | Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | Authors: | Shang, G, Zhang, C, Chen, Z.J, Bai, X, Zhang, X. | Deposit date: | 2019-01-28 | Release date: | 2019-03-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of STING binding with and phosphorylation by TBK1. Nature, 567, 2019
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6X59
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![BU of 6x59 by Molmil](/molmil-images/mine/6x59) | The mouse cGAS catalytic domain binding to human assembled nucleosome | Descriptor: | Cyclic GMP-AMP synthase, DNA, Histone H2A type 1, ... | Authors: | Pengbiao, X, Pingwei, L, Baoyu, Z. | Deposit date: | 2020-05-25 | Release date: | 2020-09-16 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | The molecular basis of tight nuclear tethering and inactivation of cGAS. Nature, 587, 2020
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6X5A
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![BU of 6x5a by Molmil](/molmil-images/mine/6x5a) | The mouse cGAS catalytic domain binding to human nucleosome that purified from HEK293T cells | Descriptor: | Cyclic GMP-AMP synthase, DNA (natural), Histone H2A type 1, ... | Authors: | Pengbiao, X, Pingwei, L, Baoyu, Z. | Deposit date: | 2020-05-25 | Release date: | 2020-09-16 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.36 Å) | Cite: | The molecular basis of tight nuclear tethering and inactivation of cGAS. Nature, 587, 2020
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5KVD
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![BU of 5kvd by Molmil](/molmil-images/mine/5kvd) | Zika specific antibody, ZV-2, bound to ZIKA envelope DIII | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SODIUM ION, ... | Authors: | Zhao, H, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2016-07-14 | Release date: | 2016-08-03 | Last modified: | 2016-08-24 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural Basis of Zika Virus-Specific Antibody Protection. Cell, 166, 2016
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8GCR
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![BU of 8gcr by Molmil](/molmil-images/mine/8gcr) | HPV16 E6-E6AP-p53 complex | Descriptor: | Cellular tumor antigen p53, Maltose/maltodextrin-binding periplasmic protein,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Bratkowski, M.A, Wang, J.C.K, Hao, Q, Nile, A.H. | Deposit date: | 2023-03-02 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Structure of the p53 degradation complex from HPV16. Nat Commun, 15, 2024
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4KSY
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![BU of 4ksy by Molmil](/molmil-images/mine/4ksy) | |
7MHC
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![BU of 7mhc by Molmil](/molmil-images/mine/7mhc) | Structure of human STING in complex with MK-1454 | Descriptor: | (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-bis(sulfanyl)octahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein | Authors: | Lesburg, C.A. | Deposit date: | 2021-04-15 | Release date: | 2022-04-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | A kinase-cGAS cascade to synthesize a therapeutic STING activator. Nature, 603, 2022
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3JRV
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![BU of 3jrv by Molmil](/molmil-images/mine/3jrv) | |
2K36
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![BU of 2k36 by Molmil](/molmil-images/mine/2k36) | Structure ensemble Backbone and side-chain 1H, 13C, and 15N Chemical Shift Assignments, 1H-15N RDCs and 1H-1H nOe restraints for protein K7 from the Vaccinia virus | Descriptor: | Protein K7 | Authors: | Kalverda, A.P, Thompson, G.S, Vogel, A, Schr der, M, Bowie, A.G, Khan, A.R, Homans, S.W. | Deposit date: | 2008-04-22 | Release date: | 2008-10-28 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3. J.Mol.Biol., 385, 2009
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7OB3
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![BU of 7ob3 by Molmil](/molmil-images/mine/7ob3) | hSTING in complex with 3',3'-c-di-araAMP | Descriptor: | 3',3'-c-di-araAMP, Stimulator of interferon genes protein | Authors: | Smola, M, Boura, E. | Deposit date: | 2021-04-20 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations Biochemistry, 2021
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5BQX
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![BU of 5bqx by Molmil](/molmil-images/mine/5bqx) | Crystal structure of human STING in complex with 3'2'-cGAMP | Descriptor: | 3'2'-cGAMP, Stimulator of interferon genes protein | Authors: | Wu, J, Zhang, X, Chen, Z.J, Chen, C. | Deposit date: | 2015-05-29 | Release date: | 2015-06-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING. Proc.Natl.Acad.Sci.USA, 112, 2015
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7LDK
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![BU of 7ldk by Molmil](/molmil-images/mine/7ldk) | Structure of human respiratory syncytial virus nonstructural protein 2 (NS2) | Descriptor: | CHLORIDE ION, D(-)-TARTARIC ACID, Non-structural protein 2 | Authors: | Chatterjee, S, Borek, D, Otwinowski, Z, Amarasinghe, G.K, Leung, D.W. | Deposit date: | 2021-01-13 | Release date: | 2021-03-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2. Proc.Natl.Acad.Sci.USA, 118, 2021
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6GYR
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![BU of 6gyr by Molmil](/molmil-images/mine/6gyr) | Transcription factor dimerization activates the p300 acetyltransferase | Descriptor: | Histone acetyltransferase p300, ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate | Authors: | Panne, D, Ortega, E. | Deposit date: | 2018-07-01 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Transcription factor dimerization activates the p300 acetyltransferase. Nature, 562, 2018
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6XJD
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![BU of 6xjd by Molmil](/molmil-images/mine/6xjd) | Two mouse cGAS catalytic domain binding to human assembled nucleosome | Descriptor: | Cyclic GMP-AMP synthase, DNA (145-MER), Histone H2A type 1, ... | Authors: | Xu, P, Li, P, Zhao, B. | Deposit date: | 2020-06-23 | Release date: | 2020-09-16 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (6.8 Å) | Cite: | The molecular basis of tight nuclear tethering and inactivation of cGAS. Nature, 587, 2020
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6DNK
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![BU of 6dnk by Molmil](/molmil-images/mine/6dnk) | Human Stimulator of Interferon Genes | Descriptor: | Stimulator of interferon genes protein, cGAMP | Authors: | Fernandez, D, Li, L, Ergun, S.L. | Deposit date: | 2018-06-06 | Release date: | 2019-03-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition. Cell, 178, 2019
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6O8C
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![BU of 6o8c by Molmil](/molmil-images/mine/6o8c) | Crystal structure of STING CTT in complex with TBK1 | Descriptor: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | Authors: | Li, P, Zhao, B, Du, F. | Deposit date: | 2019-03-09 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature, 569, 2019
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4XR8
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![BU of 4xr8 by Molmil](/molmil-images/mine/4xr8) | Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ... | Authors: | Martinez-Zapien, D, Ruiz, F.X, Mitschler, A, Podjarny, A, Trave, G, Zanier, K. | Deposit date: | 2015-01-20 | Release date: | 2016-02-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature, 529, 2016
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6O8B
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![BU of 6o8b by Molmil](/molmil-images/mine/6o8b) | Crystal structure of STING CTD in complex with TBK1 | Descriptor: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | Authors: | Li, P, Zhao, B, Du, F. | Deposit date: | 2019-03-09 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature, 569, 2019
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5GVS
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![BU of 5gvs by Molmil](/molmil-images/mine/5gvs) | Crystal structure of the DDX41 DEAD domain in an apo open form | Descriptor: | Probable ATP-dependent RNA helicase DDX41 | Authors: | Omura, H, Oikawa, D, Nakane, T, Kato, M, Ishii, R, Goto, Y, Suga, H, Ishitani, R, Tokunaga, F, Nureki, O. | Deposit date: | 2016-09-06 | Release date: | 2016-10-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide Sci Rep, 6, 2016
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5GVR
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![BU of 5gvr by Molmil](/molmil-images/mine/5gvr) | Crystal structure of the DDX41 DEAD domain in an apo closed form | Descriptor: | (2S)-2-hydroxybutanedioic acid, Probable ATP-dependent RNA helicase DDX41 | Authors: | Omura, H, Oikawa, D, Nakane, T, Kato, M, Ishii, R, Goto, Y, Suga, H, Ishitani, R, Tokunaga, F, Nureki, O. | Deposit date: | 2016-09-06 | Release date: | 2016-10-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide Sci Rep, 6, 2016
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