PDB: 42308 resultsInfo pagesStatus searchChemie searchBIRD

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5EWZ	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, GRB2-associated-binding protein 2 Authors: Bier, D, Ottmann, C. Deposit date: 2015-11-23 Release date: 2016-05-04 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
5M37	The molecular tweezer CLR01 stabilizes a disordered protein-protein interface Descriptor: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ... Authors: Bier, D, Ottmann, C. Deposit date: 2016-10-14 Release date: 2017-11-15 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.35 Å) Cite: The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
5M36	The molecular tweezer CLR01 stabilizes a disordered protein-protein interface Descriptor: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ... Authors: Bier, D, Ottmann, C. Deposit date: 2016-10-14 Release date: 2017-11-15 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.45 Å) Cite: The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
5M35	The molecular tweezer CLR01 stabilizes a disordered protein-protein interface Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, GLYCEROL, ... Authors: Bier, D, Ottmann, C. Deposit date: 2016-10-14 Release date: 2017-11-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.38 Å) Cite: The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
1B2U	STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE Descriptor: PROTEIN (BARNASE), PROTEIN (BARSTAR) Authors: Vaughan, C.K, Buckle, A.M, Fersht, A.R. Deposit date: 1998-12-01 Release date: 1998-12-09 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural response to mutation at a protein-protein interface. J.Mol.Biol., 286, 1999
1B2S	STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE Descriptor: PROTEIN (BARNASE), PROTEIN (BARSTAR), SULFATE ION Authors: Vaughan, C.K, Buckle, A.M, Fersht, A.R. Deposit date: 1998-11-30 Release date: 1998-12-08 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Structural response to mutation at a protein-protein interface. J.Mol.Biol., 286, 1999
1B3S	STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE Descriptor: PROTEIN (BARNASE), PROTEIN (BARSTAR) Authors: Vaughan, C.K, Buckle, A.M, Fersht, A.R. Deposit date: 1998-12-01 Release date: 1998-12-09 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Structural response to mutation at a protein-protein interface. J.Mol.Biol., 286, 1999
1B27	STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE Descriptor: PROTEIN (BARNASE), PROTEIN (BARSTAR) Authors: Vaughan, C.K, Buckle, A.M, Fersht, A.R. Deposit date: 1998-12-04 Release date: 1998-12-09 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural response to mutation at a protein-protein interface. J.Mol.Biol., 286, 1999
5GN8	Structure of a 48-mer protein nanocage fabricated from its 24-mer analogue by subunit interface redesign Descriptor: CALCIUM ION, Ferritin heavy chain Authors: Zhang, S, Zang, J, Zhao, G, Mikami, B. Deposit date: 2016-07-19 Release date: 2016-12-14 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.805 Å) Cite: "Silent" Amino Acid Residues at Key Subunit Interfaces Regulate the Geometry of Protein Nanocages ACS Nano, 10, 2016
8TJF	monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-CL interface Descriptor: Fab Lambda light chain, IgG1 Fab heavy chain Authors: Oganesyan, V.Y, van Dyk, N, Mazor, Y, Chiang, C. Deposit date: 2023-07-21 Release date: 2023-11-22 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C H 1-C lambda interface. Mabs, 15, 2023
8TI4	monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-CL interface Descriptor: GLYCEROL, IgG1 Fab heavy chain, mutated to promote correct pairing, ... Authors: Oganesyan, V.Y, van Dyk, N, Mazor, Y. Deposit date: 2023-07-19 Release date: 2023-11-22 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C H 1-C lambda interface. Mabs, 15, 2023
1AXI	STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE Descriptor: GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION Authors: Atwell, S, Ultsch, M, De Vos, A.M, Wells, J.A. Deposit date: 1997-10-15 Release date: 1998-01-28 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural plasticity in a remodeled protein-protein interface. Science, 278, 1997
1YM5	Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily. Descriptor: Hypothetical 32.6 kDa protein in DAP2-SLT2 intergenic region Authors: Liger, D, Quevillon-Cheruel, S, Sorel, I, Bremang, M, Blondeau, K, Aboulfath, I, Janin, J, Van Tilbeurgh, H, Leulliot, N, Paris-Sud Yeast Structural Genomics (YSG) Deposit date: 2005-01-20 Release date: 2005-08-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily Proteins, 60, 2005
4BED	Keyhole limpet hemocyanin (KLH): 9A cryoEM structure and molecular model of the KLH1 didecamer reveal the interfaces and intricate topology of the 160 functional units Descriptor: CU2-O2 CLUSTER, HEMOCYANIN KLH1 Authors: Gatsogiannis, C, Markl, J. Deposit date: 2013-03-08 Release date: 2013-12-25 Last modified: 2024-10-09 Method: ELECTRON MICROSCOPY (9 Å) Cite: Keyhole Limpet Hemocyanin: 9-A Cryoem Structure and Molecular Model of the Klh1 Didecamer Reveal the Interfaces and Intricate Topology of the 160 Functional Units. J.Mol.Biol., 385, 2009
6GJQ	human NBD1 of CFTR in complex with nanobody T27 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, Nanobody T27 Authors: Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. Deposit date: 2018-05-16 Release date: 2019-06-19 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
6GKD	human NBD1 of CFTR in complex with nanobodies D12 and G3a Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, GLYCEROL, ... Authors: Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. Deposit date: 2018-05-18 Release date: 2019-06-19 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
6GJS	Human NBD1 of CFTR in complex with nanobodies D12 and T4 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ... Authors: Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. Deposit date: 2018-05-16 Release date: 2019-06-26 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
6GK4	Human NBD1 of CFTR in complex with nanobodies D12 and T8 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, GLYCEROL, ... Authors: Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. Deposit date: 2018-05-18 Release date: 2019-06-19 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.91 Å) Cite: Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
6GJU	human NBD1 of CFTR in complex with nanobodies T2a and T4 Descriptor: Cystic fibrosis transmembrane conductance regulator, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. Deposit date: 2018-05-17 Release date: 2019-06-26 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
5DWX	Structural Insights into the Quadruplex-Duplex 3' Interface formed from a Telomeric Repeat - TLOOP Descriptor: DNA (24-MER), DNA complementary strand, POTASSIUM ION Authors: Parkinson, G.N, Russo Krauss, I. Deposit date: 2015-09-23 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Structural Insights into the Quadruplex-Duplex 3' Interface Formed from a Telomeric Repeat: A Potential Molecular Target. J.Am.Chem.Soc., 138, 2016
1B48	CRYSTAL STRUCTURE OF MGSTA4-4 IN COMPLEX WITH GSH CONJUGATE OF 4-HYDROXYNONENAL IN ONE SUBUNIT AND GSH IN THE OTHER: EVIDENCE OF SIGNALING ACROSS DIMER INTERFACE IN MGSTA4-4 Descriptor: 4-S-GLUTATHIONYL-5-PENTYL-TETRAHYDRO-FURAN-2-OL, GLUTATHIONE, PROTEIN (GLUTATHIONE S-TRANSFERASE) Authors: Xiao, B, Zimniak, P, Ji, X. Deposit date: 1999-01-06 Release date: 1999-09-29 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of a murine glutathione S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other: evidence of signaling across the dimer interface. Biochemistry, 38, 1999
6GC2	AbLIFT: Antibody stability and affinity optimization by computational design of the variable light-heavy chain interface Descriptor: Heavy chain, Light Chain Authors: Warszawski, S, Katz, A, Khmelnitsky, L, Ben Nissan, G, Javitt, G, Dym, O, Unger, T, Knop, O, Diskin, R, Albeck, S, Fass, D, Sharon, M, Fleishman, S.J. Deposit date: 2018-04-17 Release date: 2019-05-01 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces. Plos Comput.Biol., 15, 2019
5DWW	Structural Insights into the Quadruplex-Duplex 3' Interface formed from a Telomeric Repeat - TTLOOP Descriptor: DNA (25-MER), DNA (5'-D(*TP*AP*AP*CP*GP*CP*TP*A)-3'), POTASSIUM ION Authors: Russo Krauss, I, Parkinson, G.N. Deposit date: 2015-09-23 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.79 Å) Cite: Structural Insights into the Quadruplex-Duplex 3' Interface Formed from a Telomeric Repeat: A Potential Molecular Target. J.Am.Chem.Soc., 138, 2016
2VRN	The structure of the stress response protein DR1199 from Deinococcus radiodurans: a member of the DJ-1 superfamily Descriptor: MAGNESIUM ION, PROTEASE I Authors: Fioravanti, E, Dura, M.A, Lascoux, D, Micossi, E, McSweeney, S. Deposit date: 2008-04-09 Release date: 2008-10-28 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structure of the stress response protein DR1199 from Deinococcus radiodurans: a member of the DJ-1 superfamily. Biochemistry, 47, 2008
5VHT	E. coli chorismate mutase with orthogonal interface containing p-benzoyl phenylalanine Descriptor: Chorismate Mutase Authors: Koh, M, Nasertorabi, F, Han, G.W, Stevens, R.C, Shultz, P.G. Deposit date: 2017-04-13 Release date: 2017-05-10 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid. J. Am. Chem. Soc., 139, 2017

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