6GC2

AbLIFT: Antibody stability and affinity optimization by computational design of the variable light-heavy chain interface

Summary for 6GC2

• Entry DOI: 10.2210/pdb6gc2/pdb
• Descriptor: Light Chain, Heavy chain (3 entities in total)
• Functional Keywords: antibody, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 51742.77

Authors

Warszawski, S.,Katz, A.,Khmelnitsky, L.,Ben Nissan, G.,Javitt, G.,Dym, O.,Unger, T.,Knop, O.,Diskin, R.,Albeck, S.,Fass, D.,Sharon, M.,Fleishman, S.J. (deposition date: 2018-04-17, release date: 2019-05-01, Last modification date: 2024-01-17)

• Primary citation: Warszawski, S.,Katz, A.B.,Lipsh, R.,Khmelnitsky, L.,Ben Nissan, G.,Javitt, G.,Dym, O.,Unger, T.,Knop, O.,Albeck, S.,Diskin, R.,Fass, D.,Sharon, M.,Fleishman, S.J.; Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.; Plos Comput.Biol., 15:e1007207-e1007207, 2019; PubMed: 31442220; DOI: 10.1371/journal.pcbi.1007207

Experimental method

X-RAY DIFFRACTION (2.55 Å)