6GJU

human NBD1 of CFTR in complex with nanobodies T2a and T4

Summary for 6GJU

Entry DOI	10.2210/pdb6gju/pdb
Descriptor	Cystic fibrosis transmembrane conductance regulator, Nanobody T4, Nanobody T2a, ... (6 entities in total)
Functional Keywords	cystic fibrosis, cftr, nanobodies, thermal stabilization, conformational dynamics, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	60725.03
Authors	Sigoillot, M.,Overtus, M.,Grodecka, M.,Scholl, D.,Garcia-Pino, A.,Laeremans, T.,He, L.,Pardon, E.,Hildebrandt, E.,Urbatsch, I.,Steyaert, J.,Riordan, J.R.,Govaerts, C. (deposition date: 2018-05-17, release date: 2019-06-26, Last modification date: 2024-01-17)
Primary citation	Sigoillot, M.,Overtus, M.,Grodecka, M.,Scholl, D.,Garcia-Pino, A.,Laeremans, T.,He, L.,Pardon, E.,Hildebrandt, E.,Urbatsch, I.,Steyaert, J.,Riordan, J.R.,Govaerts, C. Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10:2636-2636, 2019 Cited by PubMed: 31201318 DOI: 10.1038/s41467-019-10714-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation