6GJU
human NBD1 of CFTR in complex with nanobodies T2a and T4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cystic fibrosis transmembrane conductance regulator | polymer | 261 | 29218.4 | 1 | UniProt (Q20BJ8) Pfam (PF00005) UniProt (by SIFTS) (P13569) | Homo sapiens (Human) | ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B (B) | Nanobody T4 | polymer | 143 | 15488.1 | 1 | Lama glama (llama) | ||
| 3 | C (C) | Nanobody T2a | polymer | 146 | 15820.3 | 1 | Lama glama (llama) | ||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | F, G, H (A, B, C) | water | water | 18.0 | 83 | Chemie (HOH) |
Sequence modifications
A: 387 - 646 (UniProt: Q20BJ8)
| PDB | External Database | Details |
|---|---|---|
| Ser 386 | - | expression tag |
| Pro 492 | Ser 492 | engineered mutation |
| Pro 534 | Ala 534 | engineered mutation |
| Thr 539 | Ile 539 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 60526.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 198.2 | |
| All* | Total formula weight | 60725.0 |
