8TJF

monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-CL interface

Summary for 8TJF

Entry DOI	10.2210/pdb8tjf/pdb
Descriptor	Fab Lambda light chain, IgG1 Fab heavy chain (3 entities in total)
Functional Keywords	igg1 antigen binding fragment, mutated, immune system
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	93888.68
Authors	Oganesyan, V.Y.,van Dyk, N.,Mazor, Y.,Chiang, C. (deposition date: 2023-07-21, release date: 2023-11-22)
Primary citation	Bagert, J.D.,Oganesyan, V.,Chiang, C.I.,Iannotti, M.,Lin, J.,Yang, C.,Payne, S.,McMahon, W.,Edwards, S.,Dippel, A.,Hutchinson, M.,Huang, F.,Aleti, V.,Niu, C.,Qian, C.,Denham, J.,Ferreira, S.,Pradhan, P.,Penney, M.,Wang, C.,Liu, W.,Walseng, E.,Mazor, Y. Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C H 1-C lambda interface. Mabs, 15:2273449-2273449, 2023 Cited by PubMed: 37930310 DOI: 10.1080/19420862.2023.2273449 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation