5M36

The molecular tweezer CLR01 stabilizes a disordered protein-protein interface

Replaces:  5JIV

Summary for 5M36

• Entry DOI: 10.2210/pdb5m36/pdb
• Related: 4JDD 5EWZ 5EXA
• Descriptor: 14-3-3 protein zeta/delta, M-phase inducer phosphatase 3, (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, ... (6 entities in total)
• Functional Keywords: stabilization, 14-3-3, disordered ppi interface, cdc25c, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 64984.70

Authors

Bier, D.,Ottmann, C. (deposition date: 2016-10-14, release date: 2017-11-15, Last modification date: 2024-01-17)

• Primary citation: Bier, D.,Mittal, S.,Bravo-Rodriguez, K.,Sowislok, A.,Guillory, X.,Briels, J.,Heid, C.,Bartel, M.,Wettig, B.,Brunsveld, L.,Sanchez-Garcia, E.,Schrader, T.,Ottmann, C.; The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface.; J. Am. Chem. Soc., 139:16256-16263, 2017; PubMed: 29039919; DOI: 10.1021/jacs.7b07939

Experimental method

X-RAY DIFFRACTION (2.45 Å)