6GK4

Human NBD1 of CFTR in complex with nanobodies D12 and T8

Summary for 6GK4

• Entry DOI: 10.2210/pdb6gk4/pdb
• Descriptor: Cystic fibrosis transmembrane conductance regulator, Nanobody D12, Nanobody T8, ... (7 entities in total)
• Functional Keywords: cystic fibrosis, cftr, nanobodies, thermal stabilization, conformational dynamics, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 115469.45

Authors

Sigoillot, M.,Overtus, M.,Grodecka, M.,Scholl, D.,Garcia-Pino, A.,Laeremans, T.,He, L.,Pardon, E.,Hildebrandt, E.,Urbatsch, I.,Steyaert, J.,Riordan, J.R.,Govaerts, C. (deposition date: 2018-05-18, release date: 2019-06-19, Last modification date: 2019-08-21)

• Primary citation: Sigoillot, M.,Overtus, M.,Grodecka, M.,Scholl, D.,Garcia-Pino, A.,Laeremans, T.,He, L.,Pardon, E.,Hildebrandt, E.,Urbatsch, I.,Steyaert, J.,Riordan, J.R.,Govaerts, C.; Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.; Nat Commun, 10:2636-2636, 2019; PubMed: 31201318; DOI: 10.1038/s41467-019-10714-y

Experimental method

X-RAY DIFFRACTION (2.91 Å)