6GK4
Human NBD1 of CFTR in complex with nanobodies D12 and T8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Cystic fibrosis transmembrane conductance regulator | polymer | 229 | 25525.4 | 2 | UniProt (Q20BJ8) Pfam (PF00005) UniProt (by SIFTS) (P13569) | Homo sapiens (Human) | ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B, E (B, E) | Nanobody D12 | polymer | 149 | 16273.9 | 2 | Lama glama | ||
| 3 | C, F (C, F) | Nanobody T8 | polymer | 143 | 15357.8 | 2 | Lama glama | ||
| 4 | G (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | H, K (A, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | I, J (A, D) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 7 | L, M, N, O, P... (A, B, C, D, E...) | water | water | 18.0 | 237 | Chemie (HOH) |
Sequence modifications
A, D: 387 - 646 (UniProt: Q20BJ8)
| PDB | External Database | Details |
|---|---|---|
| Ser 386 | - | expression tag |
| - | Phe 405 | deletion |
| - | Gly 406 | deletion |
| - | Glu 407 | deletion |
| - | Leu 408 | deletion |
| - | Phe 409 | deletion |
| - | Glu 410 | deletion |
| - | Lys 411 | deletion |
| - | Ala 412 | deletion |
| - | Lys 413 | deletion |
| - | Gln 414 | deletion |
| - | Asn 415 | deletion |
| - | Asn 416 | deletion |
| - | Asn 417 | deletion |
| - | Asn 418 | deletion |
| - | Arg 419 | deletion |
| - | Lys 420 | deletion |
| - | Thr 421 | deletion |
| - | Ser 422 | deletion |
| - | Asn 423 | deletion |
| - | Gly 424 | deletion |
| - | Asp 425 | deletion |
| - | Asp 426 | deletion |
| - | Ser 427 | deletion |
| - | Leu 428 | deletion |
| - | Phe 429 | deletion |
| - | Phe 430 | deletion |
| - | Ser 431 | deletion |
| - | Asn 432 | deletion |
| - | Phe 433 | deletion |
| - | Ser 434 | deletion |
| - | Leu 435 | deletion |
| - | Leu 436 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 114314.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1155.1 | |
| All* | Total formula weight | 115469.4 |
