6GK4
Human NBD1 of CFTR in complex with nanobodies D12 and T8
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 701 |
| Chain | Residue |
| A | ASP529 |
| A | SER549 |
| A | ARG555 |
| A | HOH810 |
| B | ASP61 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 702 |
| Chain | Residue |
| A | THR465 |
| A | GLN493 |
| A | ATP703 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue ATP A 703 |
| Chain | Residue |
| A | VAL440 |
| A | GLY461 |
| A | GLY463 |
| A | LYS464 |
| A | THR465 |
| A | SER466 |
| A | GLN493 |
| A | MG702 |
| C | SER30 |
| A | TRP401 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue ATP D 701 |
| Chain | Residue |
| D | TRP401 |
| D | THR460 |
| D | GLY461 |
| D | ALA462 |
| D | GLY463 |
| D | LYS464 |
| D | THR465 |
| D | SER466 |
| D | GLN493 |
| D | MG702 |
| D | HOH806 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue MG D 702 |
| Chain | Residue |
| D | THR465 |
| D | GLN493 |
| D | ASP572 |
| D | SER573 |
| D | VAL603 |
| D | ATP701 |
| D | HOH806 |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRARISLARAV |
| Chain | Residue | Details |
| A | LEU548-VAL562 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15528182","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20150177","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PZE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PZF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PZG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15528182","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15528182","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"22119790","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
