6GK4
Human NBD1 of CFTR in complex with nanobodies D12 and T8
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 701 |
| Chain | Residue |
| A | ASP529 |
| A | SER549 |
| A | ARG555 |
| A | HOH810 |
| B | ASP61 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 702 |
| Chain | Residue |
| A | THR465 |
| A | GLN493 |
| A | ATP703 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue ATP A 703 |
| Chain | Residue |
| A | VAL440 |
| A | GLY461 |
| A | GLY463 |
| A | LYS464 |
| A | THR465 |
| A | SER466 |
| A | GLN493 |
| A | MG702 |
| C | SER30 |
| A | TRP401 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue ATP D 701 |
| Chain | Residue |
| D | TRP401 |
| D | THR460 |
| D | GLY461 |
| D | ALA462 |
| D | GLY463 |
| D | LYS464 |
| D | THR465 |
| D | SER466 |
| D | GLN493 |
| D | MG702 |
| D | HOH806 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue MG D 702 |
| Chain | Residue |
| D | THR465 |
| D | GLN493 |
| D | ASP572 |
| D | SER573 |
| D | VAL603 |
| D | ATP701 |
| D | HOH806 |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRARISLARAV |
| Chain | Residue | Details |
| A | LEU548-VAL562 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15528182, ECO:0000269|PubMed:20150177, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:1XMJ, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS, ECO:0007744|PDB:2BBT, ECO:0007744|PDB:2PZE, ECO:0007744|PDB:2PZF, ECO:0007744|PDB:2PZG |
| Chain | Residue | Details |
| A | TRP401 | |
| D | TRP401 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20150177, ECO:0007744|PDB:2PZE, ECO:0007744|PDB:2PZF, ECO:0007744|PDB:2PZG |
| Chain | Residue | Details |
| A | SER466 | |
| D | SER466 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434, ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:1XMJ, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS, ECO:0007744|PDB:2BBT |
| Chain | Residue | Details |
| A | PHE490 | |
| D | PHE490 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS |
| Chain | Residue | Details |
| A | GLN525 | |
| D | GLN525 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | LEU581 | |
| D | LEU581 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:22119790 |
| Chain | Residue | Details |
| A | ILE556 | |
| D | ILE556 |
