PDB: 46984 resultsInfo pagesStatus searchChemie searchBIRD

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8G2Y	Cryo-EM structure of ADGRF1 coupled to miniGs/q Descriptor: Adhesion G-protein-coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Jones, D, Rawson, S, Blacklow, S. Deposit date: 2023-02-06 Release date: 2023-05-10 Method: ELECTRON MICROSCOPY (3.44 Å) Cite: Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling. Nat Commun, 14, 2023
8FP5	CDK2 liganded with ATP and Mg2+ Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Cyclin-dependent kinase 2, ... Authors: Schonbrunn, E, Sun, L. Deposit date: 2023-01-04 Release date: 2023-05-31 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
8FOD	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in Apo state conformation II Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... Authors: Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. Deposit date: 2022-12-30 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
8FOE	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex bound to a template DNA Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... Authors: Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. Deposit date: 2022-12-30 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (5.6 Å) Cite: Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
8FOK	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the DNA elongation state Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... Authors: Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. Deposit date: 2022-12-30 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
6O1Q	The N-terminal domain of NPHP1 folds into an antiparallel three-stranded coiled coil Descriptor: Nephrocystin-1 Authors: Musco, G, Mannella, V. Deposit date: 2019-02-21 Release date: 2019-08-14 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: The N-Terminal Domain of NPHP1 Folds into a Monomeric Left-Handed Antiparallel Three-Stranded Coiled Coil with Anti-apoptotic Function. Acs Chem.Biol., 14, 2019
8FD1	Crystal structure of photoactivated rhodopsin in complex with a nanobody Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... Authors: Salom, D, Palczewski, K, Kiser, P.D. Deposit date: 2022-12-01 Release date: 2023-08-30 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (4.25 Å) Cite: Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
8FVJ	Dimeric form of HIV-1 Vif in complex with human CBF-beta, ELOB, ELOC, and CUL5 Descriptor: Core-binding factor subunit beta, Cullin-5, Elongin-B, ... Authors: Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S. Deposit date: 2023-01-19 Release date: 2023-09-06 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.54 Å) Cite: Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H. Nat Commun, 14, 2023
8FAC	Structure of the leucine-rich repeat kinase 1 monomer Descriptor: GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 1 Authors: Metcalfe, R.D, Martinez Fiesco, J.A, Zhang, P. Deposit date: 2022-11-25 Release date: 2023-08-16 Method: ELECTRON MICROSCOPY (3.92 Å) Cite: Structure and regulation of full-length human leucine-rich repeat kinase 1. Nat Commun, 14, 2023
8FD0	Crystal structure of bovine rod opsin in complex with a nanobody Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... Authors: Salom, D, Palczewski, K, Kiser, P.D. Deposit date: 2022-12-01 Release date: 2023-08-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.71 Å) Cite: Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
8FCZ	Crystal structure of ground-state rhodopsin in complex with a nanobody Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... Authors: Salom, D, Palczewski, K, Kiser, P.D. Deposit date: 2022-12-01 Release date: 2023-08-30 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.7 Å) Cite: Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
8FVI	Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5 Descriptor: Core-binding factor subunit beta, Cullin 5, DNA dC->dU-editing enzyme APOBEC-3H, ... Authors: Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S. Deposit date: 2023-01-19 Release date: 2023-09-06 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.24 Å) Cite: Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H. Nat Commun, 14, 2023
8FR3	E. coli EF-Tu in complex with KKL-55 Descriptor: 3-chloro-N-(1-propyl-1H-tetrazol-5-yl)benzamide, Elongation factor Tu, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Nguyen, H.A, Kuzmishin Nagy, A.B, Dunham, C.M. Deposit date: 2023-01-06 Release date: 2023-09-20 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Antibiotic that inhibits trans -translation blocks binding of EF-Tu to tmRNA but not to tRNA. Mbio, 14, 2023
3T5S	Structure of macrophage migration inhibitory factor from Giardia lamblia Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SULFATE ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-07-28 Release date: 2011-08-24 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia. J.Struct.Funct.Genom., 14, 2013
8FX5	Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline Descriptor: Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Vuckovic, Z, Mobbs, J.I, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. Deposit date: 2023-01-23 Release date: 2023-09-13 Method: ELECTRON MICROSCOPY (2.45 Å) Cite: Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR. Nat Commun, 14, 2023
6H64	Crystal structure of the CRD-SAT Descriptor: Galectin-3, SULFATE ION, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose Authors: Charron, C, Kriznik, A, Yelehe-Okouma, M, Jouzeau, J.-Y, Reboul, P. Deposit date: 2018-07-26 Release date: 2019-08-14 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.8 Å) Cite: CRD SAT Generated by pCARGHO: A New Efficient Lectin-Based Affinity Tag Method for Safe, Simple, and Low-Cost Protein Purification. Biotechnol J, 14, 2019
8FKM	Human Atg3 with deletions of residues 1 to 25 and 90 to 190 Descriptor: Ubiquitin-like-conjugating enzyme ATG3 Authors: Ye, Y.S, Tian, F. Deposit date: 2022-12-21 Release date: 2023-09-13 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Multifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy. Nat Commun, 14, 2023
8FBQ	Crystal structure of Plasmodium vivax glycylpeptide N-tetradecanoyltransferase (N-myristoyltransferase, NMT) bound to myristoyl-CoA and inhibitor 12b Descriptor: 1-[(3M)-3-{3-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]pyridin-2-yl}phenyl]piperazine, ACETATE ION, CHLORIDE ION, ... Authors: Fenwick, M.K, Staker, B.L, Lovell, S.W, Phan, I.Q, Early, J, Myler, P.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-11-29 Release date: 2023-10-18 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts. Nat Commun, 14, 2023
8FWF	Crystal structure of Apo form Fab235 Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... Authors: Tan, K, Kim, M, Reinherz, E.L. Deposit date: 2023-01-21 Release date: 2023-10-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility. Nat Commun, 14, 2023
8FXJ	Crystal structure of Fab460 Descriptor: ACETATE ION, CHLORIDE ION, Fab460, ... Authors: Tan, K, Kim, M, Reinherz, E.L. Deposit date: 2023-01-24 Release date: 2023-10-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility. Nat Commun, 14, 2023
8FYM	Crystal structure of Fab235 in complex with MPER peptide Descriptor: ALA-SER-LEU-TRP-ASN-TRP-PHE-ASN-ILE-THR-ASN-TRP-LEU-TRP-TYR-ILE-LYS-LYS-LYS, CHLORIDE ION, Fab235, ... Authors: Tan, K, Kim, M, Reinherz, E.L. Deposit date: 2023-01-26 Release date: 2023-10-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility. Nat Commun, 14, 2023
8FDO	SARS-CoV-2 fusion peptide epitope scaffold FP15 bound to DH1058 Descriptor: DH1058 Heavy chain, DH1058 Light chain, FP15 Authors: Kapingidza, A.B, Marston, D.J, Wrapp, D, Winters, K, Azoitei, M.L. Deposit date: 2022-12-04 Release date: 2023-10-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Engineered immunogens to elicit antibodies against conserved coronavirus epitopes. Nat Commun, 14, 2023
8FZ2	Crystal structure of Fab460 in complex with MPER peptide Descriptor: Fab460, H chain, L chain, ... Authors: Tan, K, Kim, M, Reinherz, E.L. Deposit date: 2023-01-27 Release date: 2023-10-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility. Nat Commun, 14, 2023
8FK2	The N-terminal VicR from Streptococcus mutans Descriptor: Putative response regulator CovR VicR-like protein Authors: Zhang, H, Wu, H. Deposit date: 2022-12-20 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator. Mbio, 14, 2023
8FFO	Cryo-EM structure of wildtype rabbit TRPV5 with PI(4,5)P2 in nanodiscs Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5, ... Authors: De Jesus-Perez, J.J, Moiseenkova-Bell, V.Y. Deposit date: 2022-12-09 Release date: 2023-11-01 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A. Nat Commun, 14, 2023

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