8FYM

Crystal structure of Fab235 in complex with MPER peptide

Summary for 8FYM

• Entry DOI: 10.2210/pdb8fym/pdb
• Related: 8FWF
• Descriptor: Fab235, L chain, Fab235, H chain, ALA-SER-LEU-TRP-ASN-TRP-PHE-ASN-ILE-THR-ASN-TRP-LEU-TRP-TYR-ILE-LYS-LYS-LYS, ... (7 entities in total)
• Functional Keywords: mper, membrane proximal external region, vaccucine, fab, immune system
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 12
• Total formula weight: 205276.32

Authors

Tan, K.,Kim, M.,Reinherz, E.L. (deposition date: 2023-01-26, release date: 2023-10-11, Last modification date: 2024-03-06)

• Primary citation: Tan, K.,Chen, J.,Kaku, Y.,Wang, Y.,Donius, L.,Khan, R.A.,Li, X.,Richter, H.,Seaman, M.S.,Walz, T.,Hwang, W.,Reinherz, E.L.,Kim, M.; Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility.; Nat Commun, 14:7218-7218, 2023; PubMed: 37940661; DOI: 10.1038/s41467-023-42097-6

Experimental method

X-RAY DIFFRACTION (2.45 Å)