8FZ2

Crystal structure of Fab460 in complex with MPER peptide

Summary for 8FZ2

• Entry DOI: 10.2210/pdb8fz2/pdb
• Descriptor: Fab460, L chain, Fab460, H chain, Transmembrane protein gp41 (3 entities in total)
• Functional Keywords: fab, hiv, mper, membrane-proximal external region, vaccine, immune system
• Biological source: Mus musculus; More
• Total number of polymer chains: 3
• Total formula weight: 50397.17

Authors

Tan, K.,Kim, M.,Reinherz, E.L. (deposition date: 2023-01-27, release date: 2023-10-11, Last modification date: 2024-03-06)

• Primary citation: Tan, K.,Chen, J.,Kaku, Y.,Wang, Y.,Donius, L.,Khan, R.A.,Li, X.,Richter, H.,Seaman, M.S.,Walz, T.,Hwang, W.,Reinherz, E.L.,Kim, M.; Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility.; Nat Commun, 14:7218-7218, 2023; PubMed: 37940661; DOI: 10.1038/s41467-023-42097-6

Experimental method

X-RAY DIFFRACTION (3.5 Å)