6SB3
 
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8A1S
 | | Structure of murine perforin-2 (Mpeg1) pore in twisted form | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein | | Authors: | Yu, X, Ni, T, Zhang, P, Gilbert, R. | | Deposit date: | 2022-06-02 | | Release date: | 2022-07-20 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation.
Embo J., 41, 2022
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8A1D
 | | Structure of murine perforin-2 (Mpeg1) pore in ring form | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, Macrophage-expressed gene 1 protein | | Authors: | Yu, X, Ni, T, Zhang, P, Gilbert, R. | | Deposit date: | 2022-06-01 | | Release date: | 2022-07-20 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation.
Embo J., 41, 2022
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6SB5
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5OUQ
 | | Structure of TgPLP1 MACPF domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Perforin-like protein 1 | | Authors: | Ni, T, Gilbert, R.J.C. | | Deposit date: | 2017-08-24 | | Release date: | 2018-04-11 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (5.11 Å) | | Cite: | Structures of monomeric and oligomeric forms of theToxoplasma gondiiperforin-like protein 1.
Sci Adv, 4, 2018
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5J69
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5OWN
 | | Structure of TgPLP1 MACPF domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Perforin-like protein 1 | | Authors: | Ni, T, Gilbert, R.J.C. | | Deposit date: | 2017-09-01 | | Release date: | 2018-04-11 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.11 Å) | | Cite: | Structures of monomeric and oligomeric forms of theToxoplasma gondiiperforin-like protein 1.
Sci Adv, 4, 2018
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5OUP
 | | Structure of TgPLP1 MACPF domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Perforin-like protein 1 | | Authors: | Ni, T, Gilbert, R.J.C. | | Deposit date: | 2017-08-24 | | Release date: | 2018-04-11 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Structures of monomeric and oligomeric forms of theToxoplasma gondiiperforin-like protein 1.
Sci Adv, 4, 2018
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2QQH
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6U2J
 | | EM structure of MPEG-1 (L425K, alpha conformation) soluble pre-pore complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein | | Authors: | Pang, S.S, Bayly-Jones, C. | | Deposit date: | 2019-08-20 | | Release date: | 2019-09-25 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.37 Å) | | Cite: | The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
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6U2W
 | | EM structure of MPEG-1(L425K) pre-pore complex bound to liposome | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein | | Authors: | Pang, S.S, Bayly-Jones, C. | | Deposit date: | 2019-08-20 | | Release date: | 2019-09-25 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.63 Å) | | Cite: | The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
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6U23
 | | EM structure of MPEG-1(w.t.) soluble pre-pore | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein | | Authors: | Pang, S.S, Bayly-Jones, C. | | Deposit date: | 2019-08-19 | | Release date: | 2019-09-25 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
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6U2L
 | | EM structure of MPEG-1 (L425K, beta conformation) soluble pre-pore complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein | | Authors: | Pang, S.S, Bayly-Jones, C. | | Deposit date: | 2019-08-20 | | Release date: | 2019-09-25 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
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6U2K
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6FBM
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5J67
 | | Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Astrotactin-2, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | | Authors: | Ni, T, Harlos, K, Gilbert, R.J.C. | | Deposit date: | 2016-04-04 | | Release date: | 2016-05-25 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.16 Å) | | Cite: | Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development.
Open Biology, 6, 2016
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2QP2
 | | Structure of a MACPF/perforin-like protein | | Descriptor: | CALCIUM ION, Unknown protein | | Authors: | Rosado, C.J, Buckle, A.M, Law, R.H.P, Butcher, R.E, Kan, W.T, Bird, C.H, Ung, K, Browne, K.A, Baran, K, Bashtannyk-Puhalovich, T.A, Faux, N.G, Wong, W, Porter, C.J, Pike, R.N, Ellisdon, A.M, Pearce, M.C, Bottomley, S.P, Emsley, J, Smith, A.I, Rossjohn, J, Hartland, E.L, Voskoboinik, I, Trapani, J.A, Bird, P.I, Dunstone, M.A, Whisstock, J.C. | | Deposit date: | 2007-07-22 | | Release date: | 2007-09-04 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A common fold mediates vertebrate defense and bacterial attack
Science, 317, 2007
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5J68
 | | Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Astrotactin-2, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | | Authors: | Ni, T, Harlos, K, Gilbert, R.J.C. | | Deposit date: | 2016-04-04 | | Release date: | 2016-05-25 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (5.221 Å) | | Cite: | Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development.
Open Biology, 6, 2016
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8B6U
 | | Mpf2Ba1 monomer | | Descriptor: | MAGNESIUM ION, Mpf2Ba1 | | Authors: | Marini, G, Poland, B, Leininger, C, Lukoyanova, N, Spielbauer, D, Barry, J, Altier, D, Lum, A, Scolaro, E, Perez-Ortega, C, Yalpani, N, Sandahl, G, Mabry, T, Klever, J, Nowatzki, T, Zhao, J.Z, Sethi, A, Kassa, A, Crane, V, Lu, A, Nelson, M.E, Eswar, N, Topf, M, Saibil, H.R. | | Deposit date: | 2022-09-27 | | Release date: | 2023-05-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.134 Å) | | Cite: | Structural journey of an insecticidal protein against western corn rootworm.
Nat Commun, 14, 2023
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8B6W
 | | Mpf2Ba1 pore | | Descriptor: | MAGNESIUM ION, Mpf2Ba1 | | Authors: | Marini, G, Poland, B, Leininger, C, Lukoyanova, N, Spielbauer, D, Barry, J, Altier, D, Lum, A, Scolaro, E, Perez Ortega, C, Yalpani, N, Sandahl, G, Mabry, T, Klever, J, Nowatzki, T, Zhao, J.Z, Sethi, A, Kassa, A, Crane, V, Lu, A, Nelson, M.E, Eswar, N, Topf, M, Saibil, H.R. | | Deposit date: | 2022-09-27 | | Release date: | 2023-05-31 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structural journey of an insecticidal protein against western corn rootworm.
Nat Commun, 14, 2023
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8B6V
 | | Mp2Ba1 pre-pore | | Descriptor: | MAGNESIUM ION, Mpf2Ba1 | | Authors: | Marini, G, Poland, B, Leininger, C, Lukoyanova, N, Spielbauer, D, Barry, J, Altier, D, Lum, A, Scolaro, E, Perez Ortega, C, Yalpani, N, Sandahl, G, Mabry, T, Klever, J, Nowatzki, T, Zhao, J.Z, Sethi, A, Kassa, A, Crane, V, Lu, A, Nelson, M.E, Eswar, N, Topf, M, Saibil, H.R. | | Deposit date: | 2022-09-27 | | Release date: | 2023-05-31 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural journey of an insecticidal protein against western corn rootworm.
Nat Commun, 14, 2023
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6DLW
 | | Complement component polyC9 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement component C9, beta-D-mannopyranose | | Authors: | Dunstone, M.A, Spicer, B.A, Law, R.H.P. | | Deposit date: | 2018-06-03 | | Release date: | 2018-09-12 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
Nat Commun, 9, 2018
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7PAG
 | | The pore conformation of lymphocyte perforin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Perforin-1 | | Authors: | Ivanova, M.E, Lukoyanova, N, Malhotra, S, Topf, M, Trapani, J.A, Voskoboinik, I, Saibil, H.R. | | Deposit date: | 2021-07-29 | | Release date: | 2022-02-16 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | The pore conformation of lymphocyte perforin.
Sci Adv, 8, 2022
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3T5O
 | | Crystal Structure of human Complement Component C6 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, Complement component C6, ... | | Authors: | Aleshin, A.E, Stec, B, Bankston, L.A, DiScipio, R.G, Liddington, R.C. | | Deposit date: | 2011-07-27 | | Release date: | 2012-02-01 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.869 Å) | | Cite: | Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC).
J.Biol.Chem., 287, 2012
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3OJY
 | | Crystal Structure of Human Complement Component C8 | | Descriptor: | CALCIUM ION, Complement component C8 alpha chain, Complement component C8 beta chain, ... | | Authors: | Lovelace, L.L, Cooper, C.L, Sodetz, J.M, Lebioda, L. | | Deposit date: | 2010-08-23 | | Release date: | 2011-04-13 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.
J.Biol.Chem., 286, 2011
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