8J54
 
 | | Crystal structure of RXR/DR2 complex | | Descriptor: | DNA (5'-D(*CP*AP*TP*GP*AP*CP*CP*TP*AP*CP*TP*GP*AP*CP*CP*TP*AP*G)-3'), DNA (5'-D(*CP*TP*AP*GP*GP*TP*CP*AP*GP*TP*AP*GP*GP*TP*CP*AP*TP*G)-3'), Retinoic acid receptor RXR, ... | | Authors: | Chen, Y, Jiang, L. | | Deposit date: | 2023-04-21 | | Release date: | 2024-01-17 | | Last modified: | 2024-04-17 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Structural characterization of the DNA binding mechanism of retinoic acid-related orphan receptor gamma.
Structure, 32, 2024
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2FF0
 | | Solution Structure of Steroidogenic Factor 1 DNA Binding Domain Bound to its Target Sequence in the Inhibin alpha-subunit Promoter | | Descriptor: | CTGTGGCCCTGAGCC, GGCTCAGGGCCACAG, Steroidogenic factor 1, ... | | Authors: | Little, T.H, Zhang, Y, Matulis, C.K, Weck, J, Zhang, Z, Ramachandran, A, Mayo, K.E, Radhakrishnan, I. | | Deposit date: | 2005-12-17 | | Release date: | 2006-04-11 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Sequence-specific deoxyribonucleic Acid (DNA) recognition by steroidogenic factor 1: a helix at the carboxy terminus of the DNA binding domain is necessary for complex stability.
Mol.Endocrinol., 20, 2006
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8CEF
 | | Asymmetric Dimerization in a Transcription Factor Superfamily is Promoted by Allosteric Interactions with DNA | | Descriptor: | DNA (26-MER), Nuclear receptor DNA binding domain, ZINC ION | | Authors: | Patel, A.K.M, Shaik, T.B, McEwen, A.G, Moras, D, Klaholz, B.P, Billas, I.M.L. | | Deposit date: | 2023-02-01 | | Release date: | 2023-08-09 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.486 Å) | | Cite: | Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA.
Nucleic Acids Res., 51, 2023
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2NLL
 | | RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA | | Descriptor: | DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3'), PROTEIN (RETINOIC ACID RECEPTOR), ... | | Authors: | Rastinejad, F, Perlmann, T, Evans, R.M, Sigler, P.B. | | Deposit date: | 1996-11-20 | | Release date: | 1997-03-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural determinants of nuclear receptor assembly on DNA direct repeats.
Nature, 375, 1995
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1YNW
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3M9E
 | | Thyroid hormone beta DNA binding domain homodimer with inverted palindrome TRE | | Descriptor: | DNA (5'-D(*AP*TP*TP*GP*AP*CP*CP*TP*CP*AP*GP*CP*TP*GP*AP*GP*GP*TP*CP*AP*AP*T)-3'), Thyroid hormone receptor beta, ZINC ION | | Authors: | Chen, Y. | | Deposit date: | 2010-03-22 | | Release date: | 2010-08-18 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.406 Å) | | Cite: | Structure of a thyroid hormone receptor DNA-binding domain homodimer bound to an inverted palindrome DNA response element.
Mol.Endocrinol., 24, 2010
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1R0O
 | | Crystal Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex | | Descriptor: | Ecdysone Response Element, Ecdysone receptor, Ultraspiracle protein, ... | | Authors: | Devarakonda, S, Harp, J.M, Kim, Y, Ozyhar, A, Rastinejad, F. | | Deposit date: | 2003-09-22 | | Release date: | 2003-10-21 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex
Embo J., 22, 2003
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4TNT
 | | Structure of the human mineralocorticoid receptor in complex with DNA | | Descriptor: | DNA (5'-D(*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), Mineralocorticoid receptor, ... | | Authors: | Hudson, W.H, Ortlund, E.A. | | Deposit date: | 2014-06-04 | | Release date: | 2014-09-17 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3938 Å) | | Cite: | Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.
Plos One, 9, 2014
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5L0M
 | | hLRH-1 DNA Binding Domain - 12bp Oct4 promoter complex | | Descriptor: | DNA (5'-D(*CP*TP*AP*GP*CP*CP*TP*TP*GP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*AP*AP*GP*GP*CP*TP*AP*G)-3'), GLYCEROL, ... | | Authors: | Tuntland, M.L, Ortlund, E.A. | | Deposit date: | 2016-07-27 | | Release date: | 2016-11-09 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.197 Å) | | Cite: | A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1).
J. Mol. Biol., 428, 2016
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8HBM
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5KRB
 | | GCNF DNA Binding Domain - Oct4 DR0 Complex | | Descriptor: | DNA (5'-D(*AP*GP*AP*GP*GP*TP*CP*AP*AP*GP*GP*CP*TP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*GP*CP*CP*TP*TP*GP*AP*CP*CP*TP*CP*T)-3'), Nuclear receptor subfamily 6 group A member 1, ... | | Authors: | Weikum, E.R, Ortlund, E.A. | | Deposit date: | 2016-07-07 | | Release date: | 2016-11-09 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.101 Å) | | Cite: | A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1).
J. Mol. Biol., 428, 2016
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2HAN
 | | Structural basis of heterodimeric ecdysteroid receptor interaction with natural response element hsp27 gene promoter | | Descriptor: | 5'-D(*CP*AP*AP*GP*GP*GP*TP*TP*CP*AP*AP*TP*GP*CP*AP*CP*TP*TP*GP*T)-3', 5'-D(*GP*AP*CP*AP*AP*GP*TP*GP*CP*AP*TP*TP*GP*AP*AP*CP*CP*CP*TP*T)-3', Ecdysone receptor, ... | | Authors: | Jakob, M, Kolodziejczyk, R, Orlowski, M, Krzywda, S, Kowalska, A, Dutko-Gwozdz, J, Gwozdz, T, Kochman, M, Jaskolski, M, Ozyhar, A. | | Deposit date: | 2006-06-13 | | Release date: | 2007-05-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Novel DNA-binding element within the C-terminal extension of the nuclear receptor DNA-binding domain.
Nucleic Acids Res., 35, 2007
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8IFO
 | | Crystal structure of estrogen related receptor-gamma DNA binding domain complexed with Pla2g12b promoter | | Descriptor: | DNA (5'-D(*GP*AP*GP*GP*AP*CP*AP*AP*AP*GP*GP*TP*GP*AP*AP*AP*C)-3'), DNA (5'-D(*GP*TP*TP*TP*CP*AP*CP*CP*TP*TP*TP*GP*TP*CP*CP*TP*C)-3'), Estrogen-related receptor gamma, ... | | Authors: | Xu, T, Zhen, X, Liu, J. | | Deposit date: | 2023-02-19 | | Release date: | 2023-03-29 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | ERR gamma-DBD undergoes dimerization and conformational rearrangement upon binding to the downstream site of the DR1 element.
Biochem.Biophys.Res.Commun., 656, 2023
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5VA0
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5VA7
 | | Glucocorticoid Receptor DNA Binding Domain - IL11 AP-1 recognition element Complex | | Descriptor: | DNA (5'-D(*AP*GP*GP*GP*TP*GP*AP*GP*TP*CP*AP*GP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*CP*TP*GP*AP*CP*TP*CP*AP*CP*CP*CP*T)-3'), Glucocorticoid receptor, ... | | Authors: | Weikum, E.R, Ortlund, E.A. | | Deposit date: | 2017-03-24 | | Release date: | 2017-08-09 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.153 Å) | | Cite: | Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.
Nucleic Acids Res., 45, 2017
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8RM7
 | | Crystal Structure of Human Androgen Receptor DNA Binding Domain Bound to its Response Element: MMTV-177 GRE/ARE | | Descriptor: | Isoform 2 of Androgen receptor, MMTV-177 GRE/ARE Chain C, MMTV-177 GRE/ARE, ... | | Authors: | Lee, X.Y, Helsen, C, Van Eynde, W, Voet, A, Claessens, F. | | Deposit date: | 2024-01-05 | | Release date: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural mechanism underlying variations in DNA binding by the androgen receptor.
J.Steroid Biochem.Mol.Biol., 241, 2024
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8RM6
 | | Crystal Structure of Human Androgen Receptor DNA Binding Domain Bound to its Response Element: C3(1)ARE | | Descriptor: | C3(1)ARE_Chain C, C3(1)ARE_Chain D, Isoform 2 of Androgen receptor, ... | | Authors: | Lee, X.Y, Helsen, C, Van Eynde, W, Voet, A, Claessens, F. | | Deposit date: | 2024-01-05 | | Release date: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural mechanism underlying variations in DNA binding by the androgen receptor.
J.Steroid Biochem.Mol.Biol., 241, 2024
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2GDA
 | | REFINED SOLUTION STRUCTURE OF THE GLUCOCORTICOID RECEPTOR DNA-BINDING DOMAIN | | Descriptor: | GLUCOCORTICOID RECEPTOR, ZINC ION | | Authors: | Baumann, H, Paulsen, K, Kovacs, H, Berglund, H, Wright, A.P.H, Gustafsson, J.-A, Hard, T. | | Deposit date: | 1994-03-15 | | Release date: | 1994-06-22 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Refined solution structure of the glucocorticoid receptor DNA-binding domain.
Biochemistry, 32, 1993
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7XVN
 | | Structural basis for DNA recognition feature of retinoid-related orphan receptors | | Descriptor: | DNA (5'-D(P*CP*AP*TP*GP*AP*CP*CP*TP*AP*CP*TP*GP*AP*CP*CP*TP*AP*G)-3'), DNA (5'-D(P*CP*TP*AP*GP*GP*TP*CP*AP*GP*TP*AP*GP*GP*TP*CP*AP*TP*G)-3'), Nuclear receptor ROR-gamma, ... | | Authors: | Chen, Y, Jiang, L. | | Deposit date: | 2022-05-24 | | Release date: | 2023-11-29 | | Last modified: | 2024-04-17 | | Method: | X-RAY DIFFRACTION (2.302 Å) | | Cite: | Structural characterization of the DNA binding mechanism of retinoic acid-related orphan receptor gamma.
Structure, 32, 2024
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7XV6
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7XV9
 | | Crystal structure of the Human TR4 DNA-Binding Domain | | Descriptor: | Nuclear receptor subfamily 2 group C member 2, ZINC ION | | Authors: | Liu, Y, Chen, Z. | | Deposit date: | 2022-05-21 | | Release date: | 2022-12-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.599 Å) | | Cite: | Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation.
Nucleic Acids Res., 51, 2023
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7XV8
 | | Crystal structure of the Human TR4 DNA-Binding Domain Homodimer Bound to DR1 Response Element | | Descriptor: | DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*AP*GP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*A)-3'), Nuclear receptor subfamily 2 group C member 2, ... | | Authors: | Liu, Y, Chen, Z. | | Deposit date: | 2022-05-21 | | Release date: | 2022-12-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.199 Å) | | Cite: | Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation.
Nucleic Acids Res., 51, 2023
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6FBQ
 | | Crystal Structure of the Human Retinoid X Receptor DNA-Binding Domain Bound to the Human MEp DR1 Response Element, pH 7.0 | | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, DNA (5'-D(*CP*TP*GP*GP*GP*TP*CP*AP*AP*AP*GP*TP*TP*CP*AP*TP*C)-3'), DNA (5'-D(*GP*AP*TP*GP*AP*AP*CP*TP*TP*TP*GP*AP*CP*CP*CP*AP*G)-3'), ... | | Authors: | McEwen, A.G, Poussin-Courmontagne, P, Osz, J, Rochel, N. | | Deposit date: | 2017-12-19 | | Release date: | 2018-12-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Modulation of RXR-DNA complex assembly by DNA context.
Mol. Cell. Endocrinol., 481, 2019
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6FBR
 | | Crystal Structure of the Human Retinoid X Receptor DNA-Binding Domain Bound to the Human MEp DR1 Response Element, pH 4.2 | | Descriptor: | DI(HYDROXYETHYL)ETHER, DNA (5'-D(*CP*TP*GP*GP*GP*TP*CP*AP*AP*AP*GP*TP*TP*CP*AP*TP*C)-3'), DNA (5'-D(*GP*AP*TP*GP*AP*AP*CP*TP*TP*TP*GP*AP*CP*CP*CP*AP*G)-3'), ... | | Authors: | McEwen, A.G, Poussin-Courmontagne, P, Osz, J, Rochel, N. | | Deposit date: | 2017-12-19 | | Release date: | 2018-12-05 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Modulation of RXR-DNA complex assembly by DNA context.
Mol. Cell. Endocrinol., 481, 2019
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1A6Y
 | | REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX | | Descriptor: | DNA (5'-D(*CP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*CP*(5IT)P*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*AP*GP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*G)-3'), ORPHAN NUCLEAR RECEPTOR NR1D1, ... | | Authors: | Zhao, Q, Khorasanizadeh, S, Rastinejad, F. | | Deposit date: | 1998-03-04 | | Release date: | 1998-10-21 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural elements of an orphan nuclear receptor-DNA complex.
Mol.Cell, 1, 1998
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