2A66
Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
Summary for 2A66
Entry DOI | 10.2210/pdb2a66/pdb |
Descriptor | 5'-D(*GP*TP*TP*CP*AP*AP*GP*GP*CP*CP*AP*G)-3', 5'-D(*CP*TP*GP*GP*CP*CP*TP*TP*GP*AP*AP*C)-3', Orphan nuclear receptor NR5A2, ... (6 entities in total) |
Functional Keywords | nuclear receptor, protein-dna complex, zinc finger, dna-binding domain, transcription factor, ftz-f1, c-terminal extension, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : O00482 |
Total number of polymer chains | 3 |
Total formula weight | 20725.05 |
Authors | Solomon, I.H.,Hager, J.M.,Safi, R.,McDonnell, D.P.,Redinbo, M.R.,Ortlund, E.A. (deposition date: 2005-07-01, release date: 2005-12-06, Last modification date: 2023-08-23) |
Primary citation | Solomon, I.H.,Hager, J.M.,Safi, R.,McDonnell, D.P.,Redinbo, M.R.,Ortlund, E.A. Crystal Structure of the Human LRH-1 DBD-DNA Complex Reveals Ftz-F1 Domain Positioning is Required for Receptor Activity. J.Mol.Biol., 354:1091-1102, 2005 Cited by PubMed: 16289203DOI: 10.1016/j.jmb.2005.10.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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