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2A66

Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003700molecular_functionDNA-binding transcription factor activity
A0004879molecular_functionnuclear receptor activity
A0006355biological_processregulation of DNA-templated transcription
A0008270molecular_functionzinc ion binding
A0043565molecular_functionsequence-specific DNA binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 401
ChainResidue
ACYS86
ACYS89
ACYS103
ACYS106

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 402
ChainResidue
ACYS122
ACYS128
ACYS138
ACYS141
AACT801

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ACT A 801
ChainResidue
ACYS122
AILE123
AGLU124
ACYS128
ACYS138
AZN402

Functional Information from PROSITE/UniProt
site_idPS00031
Number of Residues27
DetailsNUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CpvCg.Dkvsgy.HYglltCesCkgFFkR
ChainResidueDetails
ACYS86-ARG112

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues71
DetailsDNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407
ChainResidueDetails
AGLU83-GLU154

site_idSWS_FT_FI2
Number of Residues44
DetailsZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407
ChainResidueDetails
ACYS86-CYS106
ACYS122-CYS146

226707

PDB entries from 2024-10-30

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