2A66
Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 401 |
| Chain | Residue |
| A | CYS86 |
| A | CYS89 |
| A | CYS103 |
| A | CYS106 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 402 |
| Chain | Residue |
| A | CYS122 |
| A | CYS128 |
| A | CYS138 |
| A | CYS141 |
| A | ACT801 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 801 |
| Chain | Residue |
| A | CYS122 |
| A | ILE123 |
| A | GLU124 |
| A | CYS128 |
| A | CYS138 |
| A | ZN402 |
Functional Information from PROSITE/UniProt
| site_id | PS00031 |
| Number of Residues | 27 |
| Details | NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CpvCg.Dkvsgy.HYglltCesCkgFFkR |
| Chain | Residue | Details |
| A | CYS86-ARG112 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Zinc finger: {"description":"NR C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | Region: {"description":"C-terminal extension (CTE)","evidences":[{"source":"PubMed","id":"38409506","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16289203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27984042","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38409506","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8PKI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16289203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27984042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L0M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
