4HN6

GR DNA Binding Domain R460D/D462R - TSLP nGRE Complex

Summary for 4HN6

• Entry DOI: 10.2210/pdb4hn6/pdb
• Related: 4HN5
• Descriptor: Glucocorticoid receptor, DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), ... (5 entities in total)
• Functional Keywords: glucocorticoid receptor, steroid receptors, dna, ngre, repression, transcription, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus : P04150
• Total number of polymer chains: 4
• Total formula weight: 35581.58

Authors

Hudson, W.H.,Youn, C.E.,Ortlund, E.A. (deposition date: 2012-10-18, release date: 2012-12-12, Last modification date: 2024-02-28)

• Primary citation: Hudson, W.H.,Youn, C.,Ortlund, E.A.; The structural basis of direct glucocorticoid-mediated transrepression.; Nat.Struct.Mol.Biol., 20:53-58, 2013; PubMed: 23222642; DOI: 10.1038/nsmb.2456

Experimental method

X-RAY DIFFRACTION (2.549 Å)