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PDB: 224 results
2FK1
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BU of 2fk1 by Molmil
Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, Cu(II)-bound
Descriptor: Amyloid beta A4 protein precursor, COPPER (II) ION
Authors:Kong, G.K.-W, Parker, M.W.
Deposit date:2006-01-03
Release date:2007-01-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Studies of the Alzheimer's Amyloid Precursor Protein Copper-binding Domain Reveal How it Binds Copper Ions
J.Mol.Biol., 367, 2007
2FK2
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BU of 2fk2 by Molmil
Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, Cu(I)-bound
Descriptor: Amyloid beta A4 protein precursor, COPPER (I) ION
Authors:Kong, G.K.-W, Parker, M.W.
Deposit date:2006-01-03
Release date:2007-01-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Studies of the Alzheimer's Amyloid Precursor Protein Copper-binding Domain Reveal How it Binds Copper Ions
J.Mol.Biol., 367, 2007
2FMA
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BU of 2fma by Molmil
Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, atomic resolution
Descriptor: Amyloid beta A4 protein precursor, GLYCEROL
Authors:Kong, G.K.-W.
Deposit date:2006-01-08
Release date:2007-01-16
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (0.85 Å)
Cite:Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution.
Acta Crystallogr.,Sect.F, 63, 2007
4M1C
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BU of 4m1c by Molmil
Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40)
Descriptor: Amyloid beta A4 protein, Fab-bound IDE, heavy chain, ...
Authors:McCord, L.M, Liang, W, Farcasanu, M, Scherpelz, K, Meredith, S.C, Koide, S, Tang, W.J.
Deposit date:2013-08-02
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.5007 Å)
Cite:Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40)
To be Published
3NYJ
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BU of 3nyj by Molmil
Crystal Structure Analysis of APP E2 domain
Descriptor: Amyloid beta A4 protein, OSMIUM ION
Authors:Ha, Y, Hu, J, Lee, S, Liu, X.
Deposit date:2010-07-15
Release date:2011-06-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization.
Biochemistry, 50, 2011
3OVJ
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BU of 3ovj by Molmil
Structure of an amyloid forming peptide KLVFFA from amyloid beta in complex with orange G
Descriptor: 7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid, KLVFFA hexapeptide segment from Amyloid beta
Authors:Landau, M, Eisenberg, D.
Deposit date:2010-09-16
Release date:2011-07-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Towards a pharmacophore for amyloid.
Plos Biol., 9, 2011
4NGE
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BU of 4nge by Molmil
Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40)
Descriptor: ACETATE ION, Beta-amyloid protein 40, GLYCEROL, ...
Authors:King, J.V, Liang, W.G, Tang, W.J.
Deposit date:2013-11-01
Release date:2014-05-14
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:Molecular basis of substrate recognition and degradation by human presequence protease.
Structure, 22, 2014
4MDR
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BU of 4mdr by Molmil
Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain D190A mutant, in complex with a sorting peptide from the amyloid precursor protein (APP)
Descriptor: AP-4 complex subunit mu-1, Amyloid beta A4 protein
Authors:Ross, B.H, Lin, Y, Corales, E.A, Burgos, P.V, Mardones, G.A.
Deposit date:2013-08-23
Release date:2014-03-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Functional Characterization of Cargo-Binding Sites on the mu 4-Subunit of Adaptor Protein Complex 4.
Plos One, 9, 2014
4ONF
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BU of 4onf by Molmil
Fab fragment of 3D6 in complex with amyloid beta 1-7
Descriptor: 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein
Authors:Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S.
Deposit date:2014-01-28
Release date:2014-06-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab.
Alzheimers Res Ther, 6, 2014
4MVK
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BU of 4mvk by Molmil
Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide fragment VFFAED
Descriptor: Amyloid peptide fragment VFFAED, Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2013-09-24
Release date:2015-08-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
3PZZ
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BU of 3pzz by Molmil
Structure of an amyloid forming peptide GAIIGL (29-34) from amyloid beta
Descriptor: Amyloid beta A4 protein
Authors:Soriaga, A.B, Laganowsky, A.L, Sawaya, M.R, Eisenberg, D.
Deposit date:2010-12-14
Release date:2011-10-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Molecular basis for amyloid-beta polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
3OW9
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BU of 3ow9 by Molmil
Structure of an amyloid forming peptide KLVFFA from amyloid beta, alternate polymorph II
Descriptor: KLVFFA hexapeptide segment from Amyloid beta
Authors:Landau, M, Eisenberg, D.
Deposit date:2010-09-17
Release date:2011-08-31
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular basis for amyloid-{beta} polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
4OJF
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BU of 4ojf by Molmil
Humanised 3D6 Fab complexed to amyloid beta 1-8
Descriptor: Amyloid beta A4 protein, Humanised 3D6 Fab Heavy Chain, Humanised 3D6 Fab Light Chain
Authors:Miles, L.A, Crespi, G.A.N, Parker, M.W.
Deposit date:2014-01-21
Release date:2015-01-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-beta
ACTA CRYSTALLOGR.,SECT.F, 70, 2014
4ONG
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BU of 4ong by Molmil
Fab fragment of 3D6 in complex with amyloid beta 1-40
Descriptor: 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein, ...
Authors:Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S.
Deposit date:2014-01-28
Release date:2014-06-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab.
Alzheimers Res Ther, 6, 2014
4MVL
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BU of 4mvl by Molmil
Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40
Descriptor: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2013-09-24
Release date:2015-08-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
4MVI
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BU of 4mvi by Molmil
Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40)
Descriptor: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2013-09-24
Release date:2015-08-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
3Q2X
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BU of 3q2x by Molmil
Structure of an amyloid forming peptide NKGAII (residues 27-32) from amyloid beta
Descriptor: Amyloid beta A4 protein
Authors:Soriaga, A.B, Sawaya, M.R, Eisenberg, D.
Deposit date:2010-12-20
Release date:2011-10-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.451 Å)
Cite:Molecular basis for amyloid-beta polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
3IFN
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BU of 3ifn by Molmil
X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex
Descriptor: 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein
Authors:Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D.
Deposit date:2009-07-24
Release date:2009-11-17
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
3IFO
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BU of 3ifo by Molmil
X-ray structure of amyloid beta peptide:antibody (Abeta1-7:10D5) complex
Descriptor: 10D5 FAB antibody heavy chain, 10D5 FAB antibody light chain, Amyloid beta A4 protein
Authors:Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D.
Deposit date:2009-07-24
Release date:2009-11-17
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
3IFP
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BU of 3ifp by Molmil
X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12B4) complex
Descriptor: 12B4 FAB antibody heavy chain, 12B4 FAB antibody light chain, Amyloid beta A4 protein
Authors:Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D.
Deposit date:2009-07-24
Release date:2009-11-17
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
1AMC
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BU of 1amc by Molmil
SOLUTION STRUCTURE OF RESIDUES 1-28 OF THE AMYLOID BETA-PEPTIDE
Descriptor: AMYLOID BETA-PEPTIDE
Authors:Talafous, J, Marcinowski, K.J, Klopman, G, Zagorski, M.G.
Deposit date:1994-11-14
Release date:1995-01-26
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of residues 1-28 of the amyloid beta-peptide.
Biochemistry, 33, 1994
3IFL
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BU of 3ifl by Molmil
X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12A11) complex
Descriptor: 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein
Authors:Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D.
Deposit date:2009-07-24
Release date:2009-11-17
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
1BRC
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BU of 1brc by Molmil
RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN
Descriptor: AMYLOID BETA-PROTEIN PRECURSOR INHIBITOR DOMAIN (APPI), TRYPSIN
Authors:Perona, J.J, Fletterick, R.J.
Deposit date:1992-12-17
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Relocating a negative charge in the binding pocket of trypsin.
J.Mol.Biol., 230, 1993
8AZT
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BU of 8azt by Molmil
Type II amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42
Descriptor: Amyloid-beta precursor protein
Authors:Yang, Y, Stern, M.A, Meunier, L.A, Liu, W, Cai, Y.Q, Ericsson, M, Liu, L, Selkoe, J.D, Goedert, M, Scheres, H.W.S.
Deposit date:2022-09-06
Release date:2022-11-02
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Abundant A beta fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains.
Neuron, 111, 2023
8AZS
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BU of 8azs by Molmil
Type I amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42
Descriptor: Amyloid-beta precursor protein
Authors:Yang, Y, Stern, M.A, Meunier, L.A, Liu, W, Cai, Y.Q, Ericsson, M, Liu, L, Selkoe, J.D, Goedert, M, Scheres, H.W.S.
Deposit date:2022-09-06
Release date:2022-11-02
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Abundant A beta fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains.
Neuron, 111, 2023

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数据于2024-07-17公开中

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