2FK2

Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, Cu(I)-bound

Summary for 2FK2

Entry DOI	10.2210/pdb2fk2/pdb
Related	1OWT 2FJZ 2FK1 2FK3
Descriptor	Amyloid beta A4 protein precursor, COPPER (I) ION (3 entities in total)
Functional Keywords	alpha-beta two-layered sandwich, cu(i) coordination, apoptosis
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P05067
Total number of polymer chains	1
Total formula weight	6912.47
Authors	Kong, G.K.-W.,Parker, M.W. (deposition date: 2006-01-03, release date: 2007-01-16, Last modification date: 2023-08-30)
Primary citation	Kong, G.K.,Adams, J.J.,Harris, H.H.,Boas, J.F.,Curtain, C.C.,Galatis, D.,Masters, C.L.,Barnham, K.J.,McKinstry, W.J.,Cappai, R.,Parker, M.W. Structural Studies of the Alzheimer's Amyloid Precursor Protein Copper-binding Domain Reveal How it Binds Copper Ions J.Mol.Biol., 367:148-161, 2007 Cited by PubMed: 17239395 DOI: 10.1016/j.jmb.2006.12.041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation