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3SMB	Phenethylisothiocyanate Covalently Bound to Macrophage Migration Inhibitory Factor (MIF) Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, N-(2-phenylethyl)thioformamide, ... Authors: Crichlow, G.V, Lolis, E.J. Deposit date: 2011-06-27 Release date: 2012-10-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates. Biochemistry, 51, 2012
3GAD	Structure of apomif Descriptor: ACETIC ACID, Macrophage migration inhibitory factor-like protein, SULFATE ION Authors: Zhou, Y.-F, Su, X.-D, Shao, D, Wang, H. Deposit date: 2009-02-17 Release date: 2009-12-29 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural and functional comparison of MIF ortholog from Plasmodium yoelii with MIF from its rodent host Mol.Immunol., 47, 2010
3T5S	Structure of macrophage migration inhibitory factor from Giardia lamblia Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SULFATE ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-07-28 Release date: 2011-08-24 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia. J.Struct.Funct.Genom., 14, 2013
3DJH	Macrophage Migration Inhibitory Factor (MIF) at 1.25 A Resolution Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Crichlow, G.V, Lolis, E. Deposit date: 2008-06-23 Release date: 2008-12-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions. Biochemistry, 48, 2009
3GAC	Structure of mif with HPP Descriptor: 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ACETIC ACID, Macrophage migration inhibitory factor-like protein, ... Authors: Zhou, Y.-F, Su, X.-D, Shao, D, Wang, H. Deposit date: 2009-02-17 Release date: 2009-12-29 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and functional comparison of MIF ortholog from Plasmodium yoelii with MIF from its rodent host Mol.Immunol., 47, 2010
3U18	Chicago Sky Blue 6B, A Novel Inhibitor for Macrophage Migration Inhibitory Factor Descriptor: 1,2-ETHANEDIOL, 6,6'-[(3,3'-dimethoxybiphenyl-4,4'-diyl)di(E)diazene-2,1-diyl]bis(4-amino-5-hydroxynaphthalene-1,3-disulfonic acid), GLYCEROL, ... Authors: Asojo, O.A. Deposit date: 2011-09-29 Release date: 2012-07-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A Novel Allosteric Inhibitor of Macrophage Migration Inhibitory Factor (MIF). J.Biol.Chem., 287, 2012
4XX7	Crystal structure of M2A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2015-01-29 Release date: 2015-09-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.77 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4Z1U	MIF in complex with 1-(4-methylphenyl)-3-phenylprop-2-yn-1-one Descriptor: GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION Authors: Cho, T.Y. Deposit date: 2015-03-27 Release date: 2016-09-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21, 2017
4GRU	crystallographic and biological characterization of N- and C- terminus mutants of human MIF Descriptor: 1,4-DIETHYLENE DIOXIDE, CHLORIDE ION, Macrophage migration inhibitory factor, ... Authors: Fan, C, Lolis, E. Deposit date: 2012-08-26 Release date: 2013-09-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.92 Å) Cite: crystallographic and biological characterization of N- and C- terminus mutants of human MIF To be Published
4GRQ	Characterization of N- and C- terminus mutants of human MIF Descriptor: 2-methyl-1-[2-(propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, CHLORIDE ION, Macrophage migration inhibitory factor, ... Authors: Fan, C, Lolis, E. Deposit date: 2012-08-26 Release date: 2013-10-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Characterization of N- and C- terminus mutants of human MIF To be Published
4GRO	Crystallographic and biological characterization of N- and C- terminus mutants of human MIF Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor Authors: Fan, C, Lolis, E. Deposit date: 2012-08-26 Release date: 2013-10-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: crystallographic and biological characterization of N- and C- terminus mutants of human MIF To be Published
4GRN	crystal structure of PAAM mutant of human MIF Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SODIUM ION, ... Authors: Fan, C, Lolis, E, Rajesekaran, D. Deposit date: 2012-08-26 Release date: 2013-09-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.25 Å) Cite: crystallographic and biological chacerterization of N- and C-terminus of MIF To be Published
4GRP	Crystallographic and biological characterization of N- and C- terminus mutants of human MIF Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SULFATE ION Authors: Fan, C, Lolis, E. Deposit date: 2012-08-26 Release date: 2013-10-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Crystallographic and biological characterization of N- and C- terminus mutants of human MIF To be Published
4Z15	MIF in complex with 3-(2-furylmethyl)-2-thioxo-1,3-thiazolan-4-one Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Cho, T.Y. Deposit date: 2015-03-26 Release date: 2016-09-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21, 2017
4Z1T	MIF in complex with 4-[(4-oxo-2-thioxo-1,3-thiazolan-3-yl)methyl]benzonitrile Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Cho, T.Y. Deposit date: 2015-03-27 Release date: 2016-09-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21, 2017
5BS9	Crystal structure of N109A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2015-06-01 Release date: 2015-09-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.98 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4GRR	characterization of N- and C- terminus mutants of human MIF Descriptor: (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, CHLORIDE ION, Macrophage migration inhibitory factor, ... Authors: Fan, C, Lolis, E. Deposit date: 2012-08-26 Release date: 2013-09-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Characterization of N- and C- terminus mutants of human MIF To be Published
4GUM	Cystal structure of locked-trimer of human MIF Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor Authors: Fan, C, Lolis, E. Deposit date: 2012-08-29 Release date: 2013-07-03 Last modified: 2020-11-18 Method: X-RAY DIFFRACTION (2.33 Å) Cite: MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proc.Natl.Acad.Sci.USA, 110, 2013
5B4O	Crystal structure of Macrophage Migration Inhibitory Factor in complex with BTZO-14 Descriptor: 1,2-ETHANEDIOL, 2-pyridin-3-yl-1,3-benzothiazin-4-one, Macrophage migration inhibitory factor, ... Authors: Oki, H, Igaki, S, Moriya, Y, Hayano, Y, Habuka, N. Deposit date: 2016-04-07 Release date: 2016-04-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.37 Å) Cite: BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression Chem. Biol., 17, 2010
5BSJ	Crystal structure of S63A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2015-06-02 Release date: 2016-06-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of S63A mutant of human macrophage migration inhibitory factor To Be Published
3IJJ	Ternary Complex of Macrophage Migration Inhibitory Factor (MIF) Bound Both to 4-hydroxyphenylpyruvate and to the Allosteric Inhibitor AV1013 (R-stereoisomer) Descriptor: (2E)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid, (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ... Authors: Crichlow, G.V, Cho, Y, Lolis, E.J. Deposit date: 2009-08-04 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc.Natl.Acad.Sci.USA, 107, 2010
3IJG	Macrophage Migration Inhibitory Factor (MIF) Bound to the (R)-Stereoisomer of AV1013 Descriptor: (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, CHLORIDE ION, Macrophage migration inhibitory factor Authors: Crichlow, G.V, Cho, Y, Lolis, E.J. Deposit date: 2009-08-04 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc.Natl.Acad.Sci.USA, 107, 2010
3KAN	D-dopachrome tautomerase (D-DT)/macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP Descriptor: 4-phenylpyrimidine, CHLORIDE ION, D-dopachrome tautomerase Authors: Zierow, S, Lolis, E. Deposit date: 2009-10-19 Release date: 2011-04-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.13 Å) Cite: Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment. Faseb J., 28, 2014
3JSF	Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution Descriptor: 7-(2-fluorobenzyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION Authors: Mclean, L, Zhang, Y. Deposit date: 2009-09-10 Release date: 2009-11-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19, 2009
3HOF	Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution Descriptor: CAFFEIC ACID, Macrophage migration inhibitory factor Authors: Crawley, L, Barker, J, Cheng, R.K.Y, Wood, M, Felicetti, B. Deposit date: 2009-06-02 Release date: 2009-06-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution To be Published

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