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3IJJ

Ternary Complex of Macrophage Migration Inhibitory Factor (MIF) Bound Both to 4-hydroxyphenylpyruvate and to the Allosteric Inhibitor AV1013 (R-stereoisomer)

Summary for 3IJJ
Entry DOI10.2210/pdb3ijj/pdb
Related1CA7 3IJG
DescriptorMacrophage migration inhibitory factor, (2E)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid, 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ... (6 entities in total)
Functional Keywordsallosteric inhibition, cytokine, immune response, inflammatory response, innate immunity, isomerase, phosphoprotein, secreted
Biological sourceHomo sapiens (human)
Cellular locationSecreted : P14174
Total number of polymer chains3
Total formula weight38661.03
Authors
Crichlow, G.V.,Cho, Y.,Lolis, E.J. (deposition date: 2009-08-04, release date: 2010-06-16, Last modification date: 2023-09-06)
Primary citationCho, Y.,Crichlow, G.V.,Vermeire, J.J.,Leng, L.,Du, X.,Hodsdon, M.E.,Bucala, R.,Cappello, M.,Gross, M.,Gaeta, F.,Johnson, K.,Lolis, E.J.
Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.
Proc.Natl.Acad.Sci.USA, 107:11313-11318, 2010
Cited by
PubMed: 20534506
DOI: 10.1073/pnas.1002716107
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.25 Å)
Structure validation

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