3IJJ
Ternary Complex of Macrophage Migration Inhibitory Factor (MIF) Bound Both to 4-hydroxyphenylpyruvate and to the Allosteric Inhibitor AV1013 (R-stereoisomer)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Macrophage migration inhibitory factor | polymer | 114 | 12355.1 | 3 | UniProt (P14174) Pfam (PF01187) | Homo sapiens (human) | MIF, Phenylpyruvate tautomerase, L-dopachrome tautomerase, L-dopachrome isomerase, Glycosylation-inhibiting factor, GIF |
| 2 | D, I, M (A, B, C) | (2E)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid | non-polymer | 180.2 | 3 | Chemie (EN1) | |||
| 3 | E, J, N (A, B, C) | 3-(4-HYDROXY-PHENYL)PYRUVIC ACID | non-polymer | 180.2 | 3 | Chemie (ENO) | |||
| 4 | F, G, H, K, L... (A, B, C) | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
| 5 | O (C) | (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one | non-polymer | 231.3 | 1 | Chemie (AVR) | |||
| 6 | S, T, U (A, B, C) | water | water | 18.0 | 479 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 37065.2 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1595.9 | |
| All* | Total formula weight | 38661.0 |
