3IJG
Macrophage Migration Inhibitory Factor (MIF) Bound to the (R)-Stereoisomer of AV1013
Summary for 3IJG
Entry DOI | 10.2210/pdb3ijg/pdb |
Related | 3IJJ |
Descriptor | Macrophage migration inhibitory factor, CHLORIDE ION, (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, ... (4 entities in total) |
Functional Keywords | allosteric binding, cytokine, immune response, inflammatory response, innate immunity, isomerase, phosphoprotein, secreted |
Biological source | Homo sapiens (human) |
Cellular location | Secreted : P14174 |
Total number of polymer chains | 3 |
Total formula weight | 37650.99 |
Authors | Crichlow, G.V.,Cho, Y.,Lolis, E.J. (deposition date: 2009-08-04, release date: 2010-06-16, Last modification date: 2023-09-06) |
Primary citation | Cho, Y.,Crichlow, G.V.,Vermeire, J.J.,Leng, L.,Du, X.,Hodsdon, M.E.,Bucala, R.,Cappello, M.,Gross, M.,Gaeta, F.,Johnson, K.,Lolis, E.J. Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc.Natl.Acad.Sci.USA, 107:11313-11318, 2010 Cited by PubMed: 20534506DOI: 10.1073/pnas.1002716107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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