3JSF

Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution

Summary for 3JSF

Entry DOI	10.2210/pdb3jsf/pdb
Related	3JSG 3JTU
Descriptor	Macrophage migration inhibitory factor, 7-(2-fluorobenzyl)quinolin-8-ol, SULFATE ION, ... (4 entities in total)
Functional Keywords	protein-ligand complex, cytokine, cytoplasm, immune response, inflammatory response, innate immunity, isomerase, phosphoprotein, secreted
Biological source	Homo sapiens (human)
Cellular location	Secreted : P14174
Total number of polymer chains	3
Total formula weight	41230.57
Authors	Mclean, L.,Zhang, Y. (deposition date: 2009-09-10, release date: 2009-11-10, Last modification date: 2023-09-06)
Primary citation	McLean, L.R.,Zhang, Y.,Li, H.,Li, Z.,Lukasczyk, U.,Choi, Y.M.,Han, Z.,Prisco, J.,Fordham, J.,Tsay, J.T.,Reiling, S.,Vaz, R.J.,Li, Y. Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19:6717-, 2009 Cited by PubMed: 19836948 DOI: 10.1016/j.bmcl.2009.09.106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation