6JP8
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![BU of 6jp8 by Molmil](/molmil-images/mine/6jp8) | Rabbit Cav1.1-Bay K8644 Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhao, Y, Huang, G, Wu, J, Yan, N. | Deposit date: | 2019-03-26 | Release date: | 2019-06-12 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel. Cell, 177, 2019
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6WOT
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![BU of 6wot by Molmil](/molmil-images/mine/6wot) | Cryo-EM structure of recombinant rabbit Ryanodine Receptor type 1 mutant R164C in complex with FKBP12.6 | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ZINC ION | Authors: | Iyer, K.A, Hu, Y, Kurebayashi, N, Murayama, T, Samso, M. | Deposit date: | 2020-04-25 | Release date: | 2020-08-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM. Sci Adv, 6, 2020
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6JPB
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![BU of 6jpb by Molmil](/molmil-images/mine/6jpb) | Rabbit Cav1.1-Diltiazem Complex | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhao, Y, Huang, G, Wu, J, Yan, N. | Deposit date: | 2019-03-26 | Release date: | 2019-06-12 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel. Cell, 177, 2019
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1UGJ
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![BU of 1ugj by Molmil](/molmil-images/mine/1ugj) | Solution structure of a murine hypothetical protein from RIKEN cDNA 2310057J16 | Descriptor: | RIKEN cDNA 2310057J16 protein | Authors: | Nagashima, T, Hayashi, F, Shirouzu, M, Terada, T, Kigawa, T, Inoue, M, Yabuki, T, Aoki, M, Seki, E, Matsuda, T, Hirota, H, Yoshida, M, Tanaka, A, Osanai, T, Arakawa, T, Carninci, P, Kawai, J, Hayashizaki, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-06-16 | Release date: | 2004-08-03 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure of a murine hypothetical protein from RIKEN cDNA 2310057J16 To be Published
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6X0V
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![BU of 6x0v by Molmil](/molmil-images/mine/6x0v) | Structure of MZT2/GCP-NHD and CDK5Rap2 at position 13 of the gamma-TuRC | Descriptor: | Centrosome protein Cep215, Gamma-tubulin complex component 2, Mitotic-spindle organizing protein 2A | Authors: | Wieczorek, M, Huang, T.-L, Urnavicius, L, Hsia, K.-C, Kapoor, T.M. | Deposit date: | 2020-05-17 | Release date: | 2020-07-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | MZT Proteins Form Multi-Faceted Structural Modules in the gamma-Tubulin Ring Complex. Cell Rep, 31, 2020
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6XW2
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![BU of 6xw2 by Molmil](/molmil-images/mine/6xw2) | Crystal structure of the bright genetically encoded calcium indicator NCaMP7 based on mNeonGreen fluorescent protein | Descriptor: | CALCIUM ION, Genetically encoded calcium indicator NCaMP7 based on mNeonGreen fluorescent protein, SULFATE ION | Authors: | Boyko, K.M, Nikolaeva, A.Y, Korzhenevskiy, D.A, Lazarenko, V.A, Subach, O.M, Subach, F.V. | Deposit date: | 2020-01-22 | Release date: | 2020-01-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Novel Genetically Encoded Bright Positive Calcium Indicator NCaMP7 Based on the mNeonGreen Fluorescent Protein. Int J Mol Sci, 21, 2020
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1E8A
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![BU of 1e8a by Molmil](/molmil-images/mine/1e8a) | The three-dimensional structure of human S100A12 | Descriptor: | CALCIUM ION, S100A12 | Authors: | Moroz, O.V, Antson, A.A, Murshudov, G.N, Maitland, N.J, Dodson, G.G, Wilson, K.S, Skibshoj, I, Lukanidin, E.M, Bronstein, I.B. | Deposit date: | 2000-09-18 | Release date: | 2001-01-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The Three-Dimensional Structure of Human S100A12 Acta Crystallogr.,Sect.D, 57, 2001
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4PE5
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![BU of 4pe5 by Molmil](/molmil-images/mine/4pe5) | Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, ... | Authors: | Karakas, E, Furukawa, H. | Deposit date: | 2014-04-22 | Release date: | 2014-06-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.96 Å) | Cite: | Crystal structure of a heterotetrameric NMDA receptor ion channel. Science, 344, 2014
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6XU4
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![BU of 6xu4 by Molmil](/molmil-images/mine/6xu4) | Crystal structure of the genetically-encoded FGCaMP calcium indicator in its calcium-bound state | Descriptor: | CALCIUM ION, FGCamp | Authors: | Boyko, K.M, Nikolaeva, A.Y, Korzhenevskiy, D.A, Barykina, N.V, Subach, O.M, Subach, F.V. | Deposit date: | 2020-01-17 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | FGCaMP7, an Improved Version of Fungi-Based Ratiometric Calcium Indicator for In Vivo Visualization of Neuronal Activity. Int J Mol Sci, 21, 2020
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6LQA
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![BU of 6lqa by Molmil](/molmil-images/mine/6lqa) | voltage-gated sodium channel Nav1.5 with quinidine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Quinidine, Sodium channel protein type 5 subunit alpha | Authors: | Yan, N, Li, Z, Pan, X, Huang, G. | Deposit date: | 2020-01-13 | Release date: | 2021-03-24 | Last modified: | 2021-05-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na v 1.5 by the Antiarrhythmic Drug Quinidine*. Angew.Chem.Int.Ed.Engl., 60, 2021
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6JP5
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![BU of 6jp5 by Molmil](/molmil-images/mine/6jp5) | Rabbit Cav1.1-Nifedipine Complex | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhao, Y, Huang, G, Wu, J, Yan, N. | Deposit date: | 2019-03-25 | Release date: | 2019-06-12 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel. Cell, 177, 2019
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1FHG
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![BU of 1fhg by Molmil](/molmil-images/mine/1fhg) | HIGH RESOLUTION REFINEMENT OF TELOKIN | Descriptor: | TELOKIN | Authors: | Tomchick, D.R, Minor, W, Kiyatkin, A, Lewinski, K, Somlyo, A.V, Somlyo, A.P. | Deposit date: | 2000-08-01 | Release date: | 2000-08-23 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution. J.Mol.Biol., 227, 1992
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1TKI
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![BU of 1tki by Molmil](/molmil-images/mine/1tki) | |
1XZZ
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![BU of 1xzz by Molmil](/molmil-images/mine/1xzz) | Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor | Descriptor: | GLYCEROL, Inositol 1,4,5-trisphosphate receptor type 1 | Authors: | Bosanac, I, Yamazaki, H, Matsu-ura, T, Michikawa, T, Mikoshiba, K, Ikura, M. | Deposit date: | 2004-11-13 | Release date: | 2005-01-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor. Mol.Cell, 17, 2005
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1IQ3
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![BU of 1iq3 by Molmil](/molmil-images/mine/1iq3) | SOLUTION STRUCTURE OF THE EPS15 HOMOLOGY DOMAIN OF A HUMAN POB1 | Descriptor: | CALCIUM ION, RALBP1-INTERACTING PROTEIN (PARTNER OF RALBP1) | Authors: | Koshiba, S, Kigawa, T, Iwahara, J, Kikuchi, A, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2001-06-06 | Release date: | 2001-06-27 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1). FEBS Lett., 442, 1999
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1JFK
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![BU of 1jfk by Molmil](/molmil-images/mine/1jfk) | MINIMUM ENERGY REPRESENTATIVE STRUCTURE OF A CALCIUM BOUND EF-HAND PROTEIN FROM ENTAMOEBA HISTOLYTICA | Descriptor: | CALCIUM ION, CALCIUM-BINDING PROTEIN | Authors: | Atreya, H.S, Sahu, S.C, Bhattacharya, A, Chary, K.V.R, Govil, G. | Deposit date: | 2001-06-21 | Release date: | 2001-12-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | NMR derived solution structure of an EF-hand calcium-binding protein from Entamoeba Histolytica. Biochemistry, 40, 2001
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1JOC
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![BU of 1joc by Molmil](/molmil-images/mine/1joc) | EEA1 homodimer of C-terminal FYVE domain bound to inositol 1,3-diphosphate | Descriptor: | Early Endosomal Autoantigen 1, PHOSPHORIC ACID MONO-(2,3,4,6-TETRAHYDROXY-5-PHOSPHONOOXY-CYCLOHEXYL) ESTER, ZINC ION | Authors: | Dumas, J.J, Merithew, E, Rajamani, D, Hayes, S, Lawe, D, Corvera, S, Lambright, D.G. | Deposit date: | 2001-07-27 | Release date: | 2001-12-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Multivalent endosome targeting by homodimeric EEA1. Mol.Cell, 8, 2001
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8J6N
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![BU of 8j6n by Molmil](/molmil-images/mine/8j6n) | Crystal structure of Cystathionine gamma-lyase in complex with compound 1 | Descriptor: | 1,2-ETHANEDIOL, Cystathionine gamma-lyase, GLYCEROL, ... | Authors: | Hibi, R, Toma-Fukai, S, Shimizu, T, Hanaoka, K. | Deposit date: | 2023-04-26 | Release date: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of a cystathionine gamma-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation. Sci Rep, 13, 2023
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2Y7J
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![BU of 2y7j by Molmil](/molmil-images/mine/2y7j) | Structure of human phosphorylase kinase, gamma 2 | Descriptor: | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM | Authors: | Muniz, J.R.C, Shrestha, A, Savitsky, P, Wang, J, Rellos, P, Fedorov, O, Burgess-Brown, N, Brenner, B, Berridge, G, Elkins, J.M, Krojer, T, Vollmar, M, Che, K.H, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S. | Deposit date: | 2011-01-31 | Release date: | 2011-02-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of Human Phosphorylase Kinase, Gamma 2 To be Published
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8JU6
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![BU of 8ju6 by Molmil](/molmil-images/mine/8ju6) | Structure of human TRPV4 with antagonist GSK279 | Descriptor: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-24 | Release date: | 2024-05-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
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8JU5
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![BU of 8ju5 by Molmil](/molmil-images/mine/8ju5) | Structure of human TRPV4 with antagonist A1 | Descriptor: | 4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-24 | Release date: | 2024-05-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
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8JVI
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![BU of 8jvi by Molmil](/molmil-images/mine/8jvi) | Structure of human TRPV4 with antagonist A2 | Descriptor: | Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-28 | Release date: | 2024-05-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
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8JVJ
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![BU of 8jvj by Molmil](/molmil-images/mine/8jvj) | Structure of human TRPV4 with antagonist A2 and RhoA | Descriptor: | Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-28 | Release date: | 2024-05-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
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8OTZ
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![BU of 8otz by Molmil](/molmil-images/mine/8otz) | 48-nm repeat of the native axonemal doublet microtubule from bovine sperm | Descriptor: | ATP6V1F neighbor, CFAP97 domain containing 1, Chromosome 13 C20orf85 homolog, ... | Authors: | Leung, M.R, Zeng, J, Zhang, R, Zeev-Ben-Mordehai, T. | Deposit date: | 2023-04-21 | Release date: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural specializations of the sperm tail. Cell, 186, 2023
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2XOA
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![BU of 2xoa by Molmil](/molmil-images/mine/2xoa) | |