8J6N

Crystal structure of Cystathionine gamma-lyase in complex with compound 1

Summary for 8J6N

• Entry DOI: 10.2210/pdb8j6n/pdb
• Descriptor: Cystathionine gamma-lyase, [6-methyl-4-[(~{E})-(oxamoylhydrazinylidene)methyl]-5-oxidanyl-pyridin-3-yl]methyl dihydrogen phosphate, GLYCEROL, ... (5 entities in total)
• Functional Keywords: lyase
• Biological source: Rattus norvegicus (Rat)
• Total number of polymer chains: 12
• Total formula weight: 520647.25

Authors

Hibi, R.,Toma-Fukai, S.,Shimizu, T.,Hanaoka, K. (deposition date: 2023-04-26, release date: 2024-02-14)

• Primary citation: Echizen, H.,Hanaoka, K.,Shimamoto, K.,Hibi, R.,Toma-Fukai, S.,Ohno, H.,Sasaki, E.,Komatsu, T.,Ueno, T.,Tsuchiya, Y.,Watanabe, Y.,Otsuka, T.,Saito, H.,Nagatoishi, S.,Tsumoto, K.,Kojima, H.,Okabe, T.,Shimizu, T.,Urano, Y.; Discovery of a cystathionine gamma-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation.; Sci Rep, 13:16456-16456, 2023; PubMed: 37777556; DOI: 10.1038/s41598-023-43536-6

Experimental method

X-RAY DIFFRACTION (1.9 Å)