8J6N

Crystal structure of Cystathionine gamma-lyase in complex with compound 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004123	molecular_function	cystathionine gamma-lyase activity
A	0005516	molecular_function	calmodulin binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016829	molecular_function	lyase activity
A	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
A	0019343	biological_process	cysteine biosynthetic process via cystathionine
A	0019344	biological_process	cysteine biosynthetic process
A	0019346	biological_process	transsulfuration
A	0030170	molecular_function	pyridoxal phosphate binding
A	0030308	biological_process	negative regulation of cell growth
A	0042802	molecular_function	identical protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0044524	biological_process	protein sulfhydration
A	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
A	0047982	molecular_function	homocysteine desulfhydrase activity
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0051289	biological_process	protein homotetramerization
A	0070814	biological_process	hydrogen sulfide biosynthetic process
A	0080146	molecular_function	L-cysteine desulfhydrase activity
A	0098606	molecular_function	selenocystathionine gamma-lyase activity
A	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
A	1990830	biological_process	cellular response to leukemia inhibitory factor
A	2001234	biological_process	negative regulation of apoptotic signaling pathway
B	0004123	molecular_function	cystathionine gamma-lyase activity
B	0005516	molecular_function	calmodulin binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0008285	biological_process	negative regulation of cell population proliferation
B	0016829	molecular_function	lyase activity
B	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
B	0019343	biological_process	cysteine biosynthetic process via cystathionine
B	0019344	biological_process	cysteine biosynthetic process
B	0019346	biological_process	transsulfuration
B	0030170	molecular_function	pyridoxal phosphate binding
B	0030308	biological_process	negative regulation of cell growth
B	0042802	molecular_function	identical protein binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0044524	biological_process	protein sulfhydration
B	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
B	0047982	molecular_function	homocysteine desulfhydrase activity
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0051289	biological_process	protein homotetramerization
B	0070814	biological_process	hydrogen sulfide biosynthetic process
B	0080146	molecular_function	L-cysteine desulfhydrase activity
B	0098606	molecular_function	selenocystathionine gamma-lyase activity
B	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
B	1990830	biological_process	cellular response to leukemia inhibitory factor
B	2001234	biological_process	negative regulation of apoptotic signaling pathway
C	0004123	molecular_function	cystathionine gamma-lyase activity
C	0005516	molecular_function	calmodulin binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0008285	biological_process	negative regulation of cell population proliferation
C	0016829	molecular_function	lyase activity
C	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
C	0019343	biological_process	cysteine biosynthetic process via cystathionine
C	0019344	biological_process	cysteine biosynthetic process
C	0019346	biological_process	transsulfuration
C	0030170	molecular_function	pyridoxal phosphate binding
C	0030308	biological_process	negative regulation of cell growth
C	0042802	molecular_function	identical protein binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0044524	biological_process	protein sulfhydration
C	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
C	0047982	molecular_function	homocysteine desulfhydrase activity
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0051289	biological_process	protein homotetramerization
C	0070814	biological_process	hydrogen sulfide biosynthetic process
C	0080146	molecular_function	L-cysteine desulfhydrase activity
C	0098606	molecular_function	selenocystathionine gamma-lyase activity
C	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
C	1990830	biological_process	cellular response to leukemia inhibitory factor
C	2001234	biological_process	negative regulation of apoptotic signaling pathway
D	0004123	molecular_function	cystathionine gamma-lyase activity
D	0005516	molecular_function	calmodulin binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006749	biological_process	glutathione metabolic process
D	0008285	biological_process	negative regulation of cell population proliferation
D	0016829	molecular_function	lyase activity
D	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
D	0019343	biological_process	cysteine biosynthetic process via cystathionine
D	0019344	biological_process	cysteine biosynthetic process
D	0019346	biological_process	transsulfuration
D	0030170	molecular_function	pyridoxal phosphate binding
D	0030308	biological_process	negative regulation of cell growth
D	0042802	molecular_function	identical protein binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0044524	biological_process	protein sulfhydration
D	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
D	0047982	molecular_function	homocysteine desulfhydrase activity
D	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
D	0051289	biological_process	protein homotetramerization
D	0070814	biological_process	hydrogen sulfide biosynthetic process
D	0080146	molecular_function	L-cysteine desulfhydrase activity
D	0098606	molecular_function	selenocystathionine gamma-lyase activity
D	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
D	1990830	biological_process	cellular response to leukemia inhibitory factor
D	2001234	biological_process	negative regulation of apoptotic signaling pathway
E	0004123	molecular_function	cystathionine gamma-lyase activity
E	0005516	molecular_function	calmodulin binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0006749	biological_process	glutathione metabolic process
E	0008285	biological_process	negative regulation of cell population proliferation
E	0016829	molecular_function	lyase activity
E	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
E	0019343	biological_process	cysteine biosynthetic process via cystathionine
E	0019344	biological_process	cysteine biosynthetic process
E	0019346	biological_process	transsulfuration
E	0030170	molecular_function	pyridoxal phosphate binding
E	0030308	biological_process	negative regulation of cell growth
E	0042802	molecular_function	identical protein binding
E	0043066	biological_process	negative regulation of apoptotic process
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0044524	biological_process	protein sulfhydration
E	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
E	0047982	molecular_function	homocysteine desulfhydrase activity
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0051289	biological_process	protein homotetramerization
E	0070814	biological_process	hydrogen sulfide biosynthetic process
E	0080146	molecular_function	L-cysteine desulfhydrase activity
E	0098606	molecular_function	selenocystathionine gamma-lyase activity
E	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
E	1990830	biological_process	cellular response to leukemia inhibitory factor
E	2001234	biological_process	negative regulation of apoptotic signaling pathway
F	0004123	molecular_function	cystathionine gamma-lyase activity
F	0005516	molecular_function	calmodulin binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006629	biological_process	lipid metabolic process
F	0006749	biological_process	glutathione metabolic process
F	0008285	biological_process	negative regulation of cell population proliferation
F	0016829	molecular_function	lyase activity
F	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
F	0019343	biological_process	cysteine biosynthetic process via cystathionine
F	0019344	biological_process	cysteine biosynthetic process
F	0019346	biological_process	transsulfuration
F	0030170	molecular_function	pyridoxal phosphate binding
F	0030308	biological_process	negative regulation of cell growth
F	0042802	molecular_function	identical protein binding
F	0043066	biological_process	negative regulation of apoptotic process
F	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
F	0044524	biological_process	protein sulfhydration
F	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
F	0047982	molecular_function	homocysteine desulfhydrase activity
F	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
F	0051289	biological_process	protein homotetramerization
F	0070814	biological_process	hydrogen sulfide biosynthetic process
F	0080146	molecular_function	L-cysteine desulfhydrase activity
F	0098606	molecular_function	selenocystathionine gamma-lyase activity
F	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
F	1990830	biological_process	cellular response to leukemia inhibitory factor
F	2001234	biological_process	negative regulation of apoptotic signaling pathway
G	0004123	molecular_function	cystathionine gamma-lyase activity
G	0005516	molecular_function	calmodulin binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006629	biological_process	lipid metabolic process
G	0006749	biological_process	glutathione metabolic process
G	0008285	biological_process	negative regulation of cell population proliferation
G	0016829	molecular_function	lyase activity
G	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
G	0019343	biological_process	cysteine biosynthetic process via cystathionine
G	0019344	biological_process	cysteine biosynthetic process
G	0019346	biological_process	transsulfuration
G	0030170	molecular_function	pyridoxal phosphate binding
G	0030308	biological_process	negative regulation of cell growth
G	0042802	molecular_function	identical protein binding
G	0043066	biological_process	negative regulation of apoptotic process
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0044524	biological_process	protein sulfhydration
G	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
G	0047982	molecular_function	homocysteine desulfhydrase activity
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0051289	biological_process	protein homotetramerization
G	0070814	biological_process	hydrogen sulfide biosynthetic process
G	0080146	molecular_function	L-cysteine desulfhydrase activity
G	0098606	molecular_function	selenocystathionine gamma-lyase activity
G	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
G	1990830	biological_process	cellular response to leukemia inhibitory factor
G	2001234	biological_process	negative regulation of apoptotic signaling pathway
H	0004123	molecular_function	cystathionine gamma-lyase activity
H	0005516	molecular_function	calmodulin binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006629	biological_process	lipid metabolic process
H	0006749	biological_process	glutathione metabolic process
H	0008285	biological_process	negative regulation of cell population proliferation
H	0016829	molecular_function	lyase activity
H	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
H	0019343	biological_process	cysteine biosynthetic process via cystathionine
H	0019344	biological_process	cysteine biosynthetic process
H	0019346	biological_process	transsulfuration
H	0030170	molecular_function	pyridoxal phosphate binding
H	0030308	biological_process	negative regulation of cell growth
H	0042802	molecular_function	identical protein binding
H	0043066	biological_process	negative regulation of apoptotic process
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0044524	biological_process	protein sulfhydration
H	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
H	0047982	molecular_function	homocysteine desulfhydrase activity
H	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
H	0051289	biological_process	protein homotetramerization
H	0070814	biological_process	hydrogen sulfide biosynthetic process
H	0080146	molecular_function	L-cysteine desulfhydrase activity
H	0098606	molecular_function	selenocystathionine gamma-lyase activity
H	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
H	1990830	biological_process	cellular response to leukemia inhibitory factor
H	2001234	biological_process	negative regulation of apoptotic signaling pathway
I	0004123	molecular_function	cystathionine gamma-lyase activity
I	0005516	molecular_function	calmodulin binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006629	biological_process	lipid metabolic process
I	0006749	biological_process	glutathione metabolic process
I	0008285	biological_process	negative regulation of cell population proliferation
I	0016829	molecular_function	lyase activity
I	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
I	0019343	biological_process	cysteine biosynthetic process via cystathionine
I	0019344	biological_process	cysteine biosynthetic process
I	0019346	biological_process	transsulfuration
I	0030170	molecular_function	pyridoxal phosphate binding
I	0030308	biological_process	negative regulation of cell growth
I	0042802	molecular_function	identical protein binding
I	0043066	biological_process	negative regulation of apoptotic process
I	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
I	0044524	biological_process	protein sulfhydration
I	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
I	0047982	molecular_function	homocysteine desulfhydrase activity
I	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
I	0051289	biological_process	protein homotetramerization
I	0070814	biological_process	hydrogen sulfide biosynthetic process
I	0080146	molecular_function	L-cysteine desulfhydrase activity
I	0098606	molecular_function	selenocystathionine gamma-lyase activity
I	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
I	1990830	biological_process	cellular response to leukemia inhibitory factor
I	2001234	biological_process	negative regulation of apoptotic signaling pathway
J	0004123	molecular_function	cystathionine gamma-lyase activity
J	0005516	molecular_function	calmodulin binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006629	biological_process	lipid metabolic process
J	0006749	biological_process	glutathione metabolic process
J	0008285	biological_process	negative regulation of cell population proliferation
J	0016829	molecular_function	lyase activity
J	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
J	0019343	biological_process	cysteine biosynthetic process via cystathionine
J	0019344	biological_process	cysteine biosynthetic process
J	0019346	biological_process	transsulfuration
J	0030170	molecular_function	pyridoxal phosphate binding
J	0030308	biological_process	negative regulation of cell growth
J	0042802	molecular_function	identical protein binding
J	0043066	biological_process	negative regulation of apoptotic process
J	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
J	0044524	biological_process	protein sulfhydration
J	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
J	0047982	molecular_function	homocysteine desulfhydrase activity
J	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
J	0051289	biological_process	protein homotetramerization
J	0070814	biological_process	hydrogen sulfide biosynthetic process
J	0080146	molecular_function	L-cysteine desulfhydrase activity
J	0098606	molecular_function	selenocystathionine gamma-lyase activity
J	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
J	1990830	biological_process	cellular response to leukemia inhibitory factor
J	2001234	biological_process	negative regulation of apoptotic signaling pathway
K	0004123	molecular_function	cystathionine gamma-lyase activity
K	0005516	molecular_function	calmodulin binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006629	biological_process	lipid metabolic process
K	0006749	biological_process	glutathione metabolic process
K	0008285	biological_process	negative regulation of cell population proliferation
K	0016829	molecular_function	lyase activity
K	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
K	0019343	biological_process	cysteine biosynthetic process via cystathionine
K	0019344	biological_process	cysteine biosynthetic process
K	0019346	biological_process	transsulfuration
K	0030170	molecular_function	pyridoxal phosphate binding
K	0030308	biological_process	negative regulation of cell growth
K	0042802	molecular_function	identical protein binding
K	0043066	biological_process	negative regulation of apoptotic process
K	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
K	0044524	biological_process	protein sulfhydration
K	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
K	0047982	molecular_function	homocysteine desulfhydrase activity
K	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
K	0051289	biological_process	protein homotetramerization
K	0070814	biological_process	hydrogen sulfide biosynthetic process
K	0080146	molecular_function	L-cysteine desulfhydrase activity
K	0098606	molecular_function	selenocystathionine gamma-lyase activity
K	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
K	1990830	biological_process	cellular response to leukemia inhibitory factor
K	2001234	biological_process	negative regulation of apoptotic signaling pathway
L	0004123	molecular_function	cystathionine gamma-lyase activity
L	0005516	molecular_function	calmodulin binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006629	biological_process	lipid metabolic process
L	0006749	biological_process	glutathione metabolic process
L	0008285	biological_process	negative regulation of cell population proliferation
L	0016829	molecular_function	lyase activity
L	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
L	0019343	biological_process	cysteine biosynthetic process via cystathionine
L	0019344	biological_process	cysteine biosynthetic process
L	0019346	biological_process	transsulfuration
L	0030170	molecular_function	pyridoxal phosphate binding
L	0030308	biological_process	negative regulation of cell growth
L	0042802	molecular_function	identical protein binding
L	0043066	biological_process	negative regulation of apoptotic process
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0044524	biological_process	protein sulfhydration
L	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
L	0047982	molecular_function	homocysteine desulfhydrase activity
L	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
L	0051289	biological_process	protein homotetramerization
L	0070814	biological_process	hydrogen sulfide biosynthetic process
L	0080146	molecular_function	L-cysteine desulfhydrase activity
L	0098606	molecular_function	selenocystathionine gamma-lyase activity
L	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
L	1990830	biological_process	cellular response to leukemia inhibitory factor
L	2001234	biological_process	negative regulation of apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00868
Number of Residues	15
Details	CYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DIcmcSATKYMnGHS

Chain	Residue	Details
A	ASP204-SER218

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ARG62
C	TYR114
C	ARG119
C	GLU339
D	ARG62
D	TYR114
D	ARG119
D	GLU339
E	ARG62
E	TYR114
E	ARG119
A	TYR114
E	GLU339
H	ARG62
H	TYR114
H	ARG119
H	GLU339
J	ARG62
J	TYR114
J	ARG119
J	GLU339
K	ARG62
A	ARG119
K	TYR114
K	ARG119
K	GLU339
F	ARG62
F	TYR114
F	ARG119
F	GLU339
G	ARG62
G	TYR114
G	ARG119
A	GLU339
G	GLU339
I	ARG62
I	TYR114
I	ARG119
I	GLU339
L	ARG62
L	TYR114
L	ARG119
L	GLU339
B	ARG62
B	TYR114
B	ARG119
B	GLU339
C	ARG62

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903

Chain	Residue	Details
A	SER51
G	SER51
I	SER51
L	SER51
B	SER51
C	SER51
D	SER51
E	SER51
H	SER51
J	SER51
K	SER51
F	SER51

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250|UniProtKB:P32929

Chain	Residue	Details
A	LYS212
G	LYS212
I	LYS212
L	LYS212
B	LYS212
C	LYS212
D	LYS212
E	LYS212
H	LYS212
J	LYS212
K	LYS212
F	LYS212

---