8JU5

Structure of human TRPV4 with antagonist A1

Summary for 8JU5

• Entry DOI: 10.2210/pdb8ju5/pdb
• EMDB information: 36659
• Descriptor: Transient receptor potential cation channel subfamily V member 4,3C-GFP, 4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile (2 entities in total)
• Functional Keywords: channel, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 515367.89

Authors

Fan, J.,Lei, X. (deposition date: 2023-06-24, release date: 2024-05-08)

• Primary citation: Fan, J.,Guo, C.,Liao, D.,Ke, H.,Lei, J.,Xie, W.,Tang, Y.,Tominaga, M.,Huang, Z.,Lei, X.; Structural Pharmacology of TRPV4 Antagonists.; Adv Sci, :e2401583-e2401583, 2024; PubMed: 38659239; DOI: 10.1002/advs.202401583

Experimental method

ELECTRON MICROSCOPY (3.74 Å)