8JU5

Structure of human TRPV4 with antagonist A1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, D, C, B)	Transient receptor potential cation channel subfamily V member 4,3C-GFP	polymer	1144	128628.5	4	UniProt (Q9HBA0) Pfam (PF00023) Pfam (PF00520)	Homo sapiens (human)	TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC
2	E, F (D, B)	4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile	non-polymer		426.9	2	Chemie (F3L)

Sequence modifications

A, D, C, B: 1 - 871 (UniProt: Q9HBA0)
A, D, C, B: 872 - 1144 (PDB: 8JU5)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	514514.2
Non-Polymers*	Number of molecules	2
	Total formula weight	853.7
All*	Total formula weight	515367.9

*Water molecules are not included.