8JVJ

Structure of human TRPV4 with antagonist A2 and RhoA

Summary for 8JVJ

• Entry DOI: 10.2210/pdb8jvj/pdb
• EMDB information: 36676
• Descriptor: Transient receptor potential cation channel subfamily V member 4,3C-GFP, Transforming protein RhoA, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone (3 entities in total)
• Functional Keywords: channel, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 604001.33

Authors

Fan, J.,Lei, X. (deposition date: 2023-06-28, release date: 2024-05-08)

• Primary citation: Fan, J.,Guo, C.,Liao, D.,Ke, H.,Lei, J.,Xie, W.,Tang, Y.,Tominaga, M.,Huang, Z.,Lei, X.; Structural Pharmacology of TRPV4 Antagonists.; Adv Sci, :e2401583-e2401583, 2024; PubMed: 38659239; DOI: 10.1002/advs.202401583

Experimental method

ELECTRON MICROSCOPY (3.44 Å)