8JVJ
Structure of human TRPV4 with antagonist A2 and RhoA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Transient receptor potential cation channel subfamily V member 4,3C-GFP | polymer | 1144 | 128628.5 | 4 | UniProt (Q9HBA0) Pfam (PF00023) Pfam (PF00520) In PDB | Homo sapiens (human) | TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC |
2 | E, F, G, H | Transforming protein RhoA | polymer | 193 | 21799.2 | 4 | UniProt (P61586) Pfam (PF00071) In PDB | Homo sapiens (human) | Rho cDNA clone 12,h12 |
3 | A, B, C, D | [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | non-polymer | 572.6 | 4 | Chemie (F9M) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 601710.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 2290.5 | |
All* | Total formula weight | 604001.3 |