8JVJ

Structure of human TRPV4 with antagonist A2 and RhoA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Transient receptor potential cation channel subfamily V member 4,3C-GFP	polymer	1144	128628.5	4	UniProt (Q9HBA0) Pfam (PF00023) Pfam (PF00520)	Homo sapiens (human)	TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC
2	E, F, G, H (E, F, G, H)	Transforming protein RhoA	polymer	193	21799.2	4	UniProt (P61586) Pfam (PF00071)	Homo sapiens (human)	Rho cDNA clone 12,h12
3	I, J, K, L (A, B, C, D)	[6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone	non-polymer		572.6	4	Chemie (F9M)

Sequence modifications

A, B, C, D: 1 - 871 (UniProt: Q9HBA0)
A, B, C, D: 872 - 1144 (PDB: 8JVJ)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	601710.8
Non-Polymers*	Number of molecules	4
	Total formula weight	2290.5
All*	Total formula weight	604001.3

*Water molecules are not included.