8JVJ
Structure of human TRPV4 with antagonist A2 and RhoA
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804 |
| Chain | Residue | Details |
| E | GLY12 | |
| C | LYS535-GLY547 | |
| C | ARG594-LYS608 | |
| C | GLY723-LEU871 | |
| D | MET1-VAL469 | |
| D | LYS535-GLY547 | |
| D | ARG594-LYS608 | |
| D | GLY723-LEU871 | |
| E | ASN117 | |
| F | GLY12 | |
| F | ASN117 | |
| G | GLY12 | |
| G | ASN117 | |
| H | GLY12 | |
| H | ASN117 | |
| C | MET1-VAL469 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P62820 |
| Chain | Residue | Details |
| E | PHE30 | |
| H | PHE30 | |
| H | ASP59 | |
| H | SER160 | |
| C | SER470-TYR490 | |
| C | TYR508-MET534 | |
| C | SER548-LEU568 | |
| C | ALA573-THR593 | |
| C | ILE609-LEU636 | |
| C | VAL694-VAL722 | |
| D | SER470-TYR490 | |
| E | ASP59 | |
| D | TYR508-MET534 | |
| D | SER548-LEU568 | |
| D | ALA573-THR593 | |
| D | ILE609-LEU636 | |
| D | VAL694-VAL722 | |
| E | SER160 | |
| F | PHE30 | |
| F | ASP59 | |
| F | SER160 | |
| G | PHE30 | |
| G | ASP59 | |
| G | SER160 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: (Microbial infection) Cleavage; by yopT => ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863 |
| Chain | Residue | Details |
| E | GLY189 | |
| C | ALA569-GLU572 | |
| C | ASN637-THR665 | |
| C | LEU686-VAL693 | |
| D | TYR491-ASP507 | |
| D | ALA569-GLU572 | |
| D | ASN637-THR665 | |
| D | LEU686-VAL693 | |
| F | GLY189 | |
| G | GLY189 | |
| H | GLY189 | |
| B | TYR491-ASP507 | |
| B | ALA569-GLU572 | |
| B | ASN637-THR665 | |
| B | LEU686-VAL693 | |
| C | TYR491-ASP507 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538 |
| Chain | Residue | Details |
| E | TYR34 | |
| F | TYR34 | |
| G | TYR34 | |
| H | TYR34 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103 |
| Chain | Residue | Details |
| E | THR37 | |
| B | ARG248 | |
| C | LYS192 | |
| C | LYS197 | |
| C | ASN201 | |
| C | TYR236 | |
| C | ARG248 | |
| D | LYS192 | |
| D | LYS197 | |
| D | ASN201 | |
| D | TYR236 | |
| F | THR37 | |
| D | ARG248 | |
| G | THR37 | |
| H | THR37 | |
| A | ARG248 | |
| B | LYS192 | |
| B | LYS197 | |
| B | ASN201 | |
| B | TYR236 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: (Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305|PubMed:1328215 |
| Chain | Residue | Details |
| E | ASN41 | |
| D | ARG249 | |
| D | ASN296 | |
| D | LYS344 | |
| F | ASN41 | |
| G | ASN41 | |
| H | ASN41 | |
| B | ASN296 | |
| B | LYS344 | |
| C | ARG249 | |
| C | ASN296 | |
| C | LYS344 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0 |
| Chain | Residue | Details |
| E | GLN63 | |
| F | GLN63 | |
| G | GLN63 | |
| H | GLN63 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKG/PRKG1 => ECO:0000269|PubMed:11162591 |
| Chain | Residue | Details |
| E | SER188 | |
| D | TYR110 | |
| D | TYR253 | |
| D | TYR805 | |
| F | SER188 | |
| G | SER188 | |
| H | SER188 | |
| B | TYR253 | |
| B | TYR805 | |
| C | TYR110 | |
| C | TYR253 | |
| C | TYR805 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P61585 |
| Chain | Residue | Details |
| E | CYS190 | |
| F | CYS190 | |
| G | CYS190 | |
| H | CYS190 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | LIPID: (Microbial infection) N6-stearoyl lysine => ECO:0000269|PubMed:30061757 |
| Chain | Residue | Details |
| E | LYS185 | |
| H | LYS185 | |
| H | LYS186 | |
| H | LYS187 | |
| E | LYS186 | |
| E | LYS187 | |
| F | LYS185 | |
| F | LYS186 | |
| F | LYS187 | |
| G | LYS185 | |
| G | LYS186 | |
| G | LYS187 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | LIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P61585 |
| Chain | Residue | Details |
| E | CYS190 | |
| F | CYS190 | |
| G | CYS190 | |
| H | CYS190 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | CARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704 |
| Chain | Residue | Details |
| E | TYR34 | |
| F | TYR34 | |
| G | TYR34 | |
| H | TYR34 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059 |
| Chain | Residue | Details |
| E | THR37 | |
| F | THR37 | |
| G | THR37 | |
| H | THR37 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831 |
| Chain | Residue | Details |
| E | LYS135 | |
| F | LYS135 | |
| G | LYS135 | |
| H | LYS135 |
