8JU6

Structure of human TRPV4 with antagonist GSK279

Summary for 8JU6

Entry DOI	10.2210/pdb8ju6/pdb
EMDB information	36660
Descriptor	Transient receptor potential cation channel subfamily V member 4,3C-GFP, 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile (2 entities in total)
Functional Keywords	channel, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	516356.30
Authors	Fan, J.,Lei, X. (deposition date: 2023-06-24, release date: 2024-05-08)
Primary citation	Fan, J.,Guo, C.,Liao, D.,Ke, H.,Lei, J.,Xie, W.,Tang, Y.,Tominaga, M.,Huang, Z.,Lei, X. Structural Pharmacology of TRPV4 Antagonists. Adv Sci, :e2401583-e2401583, 2024 Cited by PubMed: 38659239 DOI: 10.1002/advs.202401583 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.45 Å)

Structure validation