8JU6

Structure of human TRPV4 with antagonist GSK279

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, D, C)	Transient receptor potential cation channel subfamily V member 4,3C-GFP	polymer	1144	128628.5	4	UniProt (Q9HBA0) Pfam (PF00023) Pfam (PF00520)	Homo sapiens (human)	TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC
2	E, F, G, H (A, B, D, C)	1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile	non-polymer		460.5	4	Chemie (XPW)

Sequence modifications

A, B, D, C: 1 - 871 (UniProt: Q9HBA0)
A, B, D, C: 872 - 1144 (PDB: 8JU6)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	514514.2
Non-Polymers*	Number of molecules	4
	Total formula weight	1842.1
All*	Total formula weight	516356.3

*Water molecules are not included.